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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

Author(s): Pham Van Khang*, Nguyen Thi Hien Lan, Le Quang Truong, Mai Thi Minh Chau, Mai Xuan Truong, Dinh Thuy Van, Nguyen Thi Quynh Anh and Lei Ma*

Volume 16, Issue 6, 2019

Page: [474 - 477] Pages: 4

DOI: 10.2174/1570178615666181102125553

Price: $65

Abstract

In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL, respectively.

Keywords: Anemarrhena asphodeloides, steroidal glycosides, HeLa, A549, anti-proliferation, cell line.

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