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Review Article

基于药物重新定位的化学诱导细胞系表达数据的综述

卷 27, 期 32, 2020

页: [5340 - 5350] 页: 11

弟呕挨: 10.2174/0929867325666181101115801

价格: $65

摘要

药物重新定位是生物医学研究的重要领域。 药物重新定位研究已转向计算方法。 大规模扰动数据库，例如连接图和基于网络的集成细胞签名库，包含许多化学诱导的基因表达谱，并为计算生物学和药物重新定位提供了巨大的机会。 原因之一是，“连接图”和基于“基于网络的集成网络签名库”数据库提供的配置文件显示了药物，疾病和基因中生物学机制的整体视图。 在本文中，我们将对这两个数据库及其在药物重新定位中的最新应用进行综述。

关键词: 药物重新定位，计算生物学，生物信息学，候选药物，连接图，基于网络的集成细胞签名库。

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