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Review Article

抗糖尿病药物能否改善与糖尿病相关的男性生殖功能（Dys）？

卷 26, 期 22, 2019

页: [4191 - 4222] 页: 32

弟呕挨: 10.2174/0929867325666181101111404

价格: $65

摘要

世界范围内糖尿病患者数量的惊人增加引起人们对该疾病对全球健康影响的关注，更不用说对社会和经济方面的影响了。此外，这种复杂的代谢紊乱与男性生殖功能障碍之间的关系令人担忧，这主要是由于年轻人在其生殖窗口顶端受该疾病影响的可能性增加，从而进一步加剧了男性生育能力的令人不安的下降。全世界。糖尿病控制的基石是血糖控制，已证明可有效避免，减少或预防疾病相关并发症的出现或发展。尽管如此，这些治疗性干预对男性生殖功能的可能影响基本上尚未被发现。为了解决这个问题，我们对几种抗糖尿病药物对男性生殖功能的影响的文献进行了严格的评估。尽管胰岛素的关键作用是明确的，如治疗后胰岛素缺乏者的生殖功能障碍恢复后所显示的，但同样显然不适用于其他抗糖尿病策略。事实上，有很多争议性的报道，可能与所使用的各种研究设计，实验模型和化合物有关，包括双胍类，磺酰脲类，麦格列汀类，噻唑烷二酮/格列酮类，胆汁酸螯合剂，糊精模拟物以及葡萄糖酸钠共转运蛋白2（SGLT2）抑制剂，胰高血糖素样肽1（GLP1），α-葡萄糖苷酶抑制剂和二肽基肽酶4（DPP4）抑制剂。这些方面构成了本次审查的重点。

关键词: 糖尿病，不育，男性生殖功能，抗糖尿病治疗，SGLT2，糖尿病问题，生殖功能障碍。

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