Title:Gold-Based Nanoparticles Systems in Phototherapy - Current Strategies
Volume: 25
Issue: 42
关键词:
光敏剂,贵金属,功能化,光动力疗法,光动力学诊断,光热疗法,联合疗法,纳米技术
摘要: Background: The understanding of the action mechanism of the nanoparticles systems
consisting of metallic nanoparticles and dyes or cytostatic molecule is crucial for searching
and designing the ideal, novel drugs. In this review, we have considered moleculefunctionalized
metallic nanoparticle systems for phototherapy.
Methods: We performed a thorough search of the high-quality peer-reviewed literature on
metallic nanoparticles systems in phototherapy, focusing on their biological importance and
the action mechanism.
Results: 138 papers were included in the mini-review. The majority of them discussed the
way of metallic nanoparticles functionalization and its impact on the biological activity of a
hybrid system.
Conclusion: In this work, we show numerous medically and chemically important development
strategies of hybrid types of drugs which can be used in phototherapy. These systems
have a high affinity to the tumor cells surface proteins which transport the nanoparticles directly
into a cell. The application of functionalized metallic nanoparticles in phototherapy improved
photophysical properties lowered cytotoxicity of commonly used photosensitizers and
facilitated the development of the third generation photosensitizers. Furthermore, this type of
nanoparticles could also be used as a cytostatic drug carrier in the chemo or combined anticancer
therapies.