Abstract
Allylic and benzylic brominations are of paramount importance in organic synthesis. They give rise to many valuable synthons leading to the production of fine chemicals, agrochemicals and pharmaceuticals. A great many bromination methods have thus been developed to conduct the titled reactions under different circumstances. The need for environmentally benign conditions to circumvent drawbacks associated with original methods has significantly enhanced the advance in this field. Herein, only methods for benzylic brominations are reviewed and outlined because alkylbenzenes are more often chosen as the model substrates for new methods development.
Keywords: Allylic and benzylic brominations, brominating agents, debromination, green chemistry, radical reaction, solvents.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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