Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities

Title:Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities

Volume: 22 Issue: 27

Author(s): Hatem M. Gaber, Sobhi M. Gomha*, Thoraya A. Farghaly*, Zeinab A. Muhammad and Mark C. Bagley

Affiliation:

• Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613,Egypt

• Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613,Egypt

Keywords: 2-arylhydrazonals, N, N-dimethylenamino-ketones, coupling reactions, α-(arylhydrazono)-β-ketoaldehydes, active methylene, nitrogen-nucleophiles.

Abstract: The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds for biomedical implementations. The data published until the end of 2017 have been covered.

Cite this article as:

Gaber M. Hatem, Gomha M. Sobhi*, Farghaly A. Thoraya*, Muhammad A. Zeinab and Bagley C. Mark, Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities, Current Organic Chemistry 2018; 22 (27) . https://dx.doi.org/10.2174/1385272822666181025145512