Abstract
The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds for biomedical implementations. The data published until the end of 2017 have been covered.
Keywords: 2-arylhydrazonals, N, N-dimethylenamino-ketones, coupling reactions, α-(arylhydrazono)-β-ketoaldehydes, active methylene, nitrogen-nucleophiles.
Graphical Abstract
Current Organic Chemistry
Title:Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities
Volume: 22 Issue: 27
Author(s): Hatem M. Gaber, Sobhi M. Gomha*, Thoraya A. Farghaly*, Zeinab A. Muhammad and Mark C. Bagley
Affiliation:
- Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613,Egypt
- Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613,Egypt
Keywords: 2-arylhydrazonals, N, N-dimethylenamino-ketones, coupling reactions, α-(arylhydrazono)-β-ketoaldehydes, active methylene, nitrogen-nucleophiles.
Abstract: The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds for biomedical implementations. The data published until the end of 2017 have been covered.
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Cite this article as:
Gaber M. Hatem, Gomha M. Sobhi*, Farghaly A. Thoraya*, Muhammad A. Zeinab and Bagley C. Mark, Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities, Current Organic Chemistry 2018; 22 (27) . https://dx.doi.org/10.2174/1385272822666181025145512
DOI https://dx.doi.org/10.2174/1385272822666181025145512 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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