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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis of Novel 2-Amino-substituted 6-Methyl-pyrimidin-4-ol Derivatives and Their Biological Evaluation

Author(s): Aleksandr P. Yengoyan*, Vergush A. Pivazyan, Emma A. Ghazaryan and Zhermen A. Azaryan

Volume 16, Issue 7, 2019

Page: [575 - 583] Pages: 9

DOI: 10.2174/1570178615666181025120951

Price: $65

Abstract

A series of novel derivatives based on 2-amino-substituted 4-methylpyrimidin-4-ols were synthesized by simple, accessible and efficient methods. 4-N-triazolyl derivatives were obtained from the corresponding 4-chloro derivatives, and O-substituted products, including compounds with a combination of the pyrimidine and oxadiazole rings in the molecule, were synthesized from the sodium salts of 2-amino-substituted pyrimidin-4-ols. The synthesized compounds showed a pronounced stimulating action on plants growth. Their growth stimulant activities were in the range of 46-93% compared to heteroauxin.

Keywords: O-Substituted 2-amino-4-methylpyrimidin-4-ols, 4-triazolylaminopyrimidines, heterocyclization, 1, 3, 4-oxadiazolylalkyloxypyrimidines, plant growth stimulant activity, heteroauxin.

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