摘要
背景：离子通道是一个大而生长的蛋白质家族。其中许多与疾病有关，因此，它们是700多种药物的目标。新离子通道的发现有助于通过计算方法从蛋白质序列预测离子通道及其类型。然而，这些方法从未得到全面的比较和评价。 目的：本文首次对离子通道序列预测因子进行了综合调查。我们描述了八个预测因子，包括五种预测离子通道的方法、它们的类型和四类电压门控通道。我们还开发并使用一个新的基准数据集对三个现有预测因子进行了比较经验分析。 结果：虽然发表了几种依赖不同设计的方法，但只有少数方法是目前可用的，并提供了广泛的预测范围。当考虑采用新的出版方法时，应要求出版后的支持和可用性。经验分析表明，离子通道预测性能较好，离子通道类型和电压门控通道类别预测性能一般。我们发现了当前方法的一个实质性弱点，即不能准确预测被分类为多个类/类型的离子通道。 结论：离子通道的几种预测因子可供最终用户使用。它们提供实际水平的预测质量。依赖于更大、更多样化的预测输入（如psionplus）的方法更准确。应该开发新的工具来处理离子通道的多标签预测。
关键词: 离子通道，电压门控离子通道，配体门控离子通道，预测。
图形摘要
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