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Review Article

ERM复合体:糖尿病引起的血管渗漏的新参与者

卷 27, 期 18, 2020

页: [3012 - 3022] 页: 11

弟呕挨: 10.2174/0929867325666181016162327

价格: $65

摘要

背景:微血管并发症仍然是糖尿病患者发病的一个重要原因，它们与医疗保健系统的重大经济负担有关。血管渗漏是糖尿病微血管并发症的早期特征之一。近年来，Ezrin、Radixin和Moesin (ERM)蛋白在糖尿病并发症分子介质作用下参与血管功能障碍。在这篇综述中，我们将介绍有关这些蛋白在血管渗漏中的作用以及它们在糖尿病微血管并发症中可能的意义的现有证据。 方法与结果: 在2017年11月至2018年1月期间，我们对电子MEDLINE数据库进行了全面的文献检索。结果，36篇文章被评论和讨论。 讨论: ERM蛋白是细胞骨架膜连接物，当在内皮细胞中被激活时，可以诱导应力纤维中的细胞骨架重组，导致局部粘连的解体和细胞旁间隙的形成，从而增加血管通透性。这些蛋白的激活是由参与糖尿病并发症的介质诱导的，如PKC激活、TNF- TNF-、年龄和氧化应激。综上所述，ERMs在维持内皮稳态中发挥重要作用，可作为一种新的治疗分子靶点，用于预防或阻止糖尿病引起的血管渗漏。

关键词: ERM复合物，ezrin，糖尿病引起的血管渗漏，内皮稳态，radixin和moesin (ERM)蛋白，TNF-α。

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