Abstract
C21 steroids glycosides of various deoxysugars have been emerging from genus of Cynanchum. Besides classical C21 glycosides, many C21 glycosides with seco-ring aglycones attracted the extensive attention of many researchers. We conducted a systematic chemical investigation on Cynanchum hancockianum, which led to the isolation of one new seco-ring C21 steroidal glycosides. The new compound was identified as cynaascyriogenin 3-O-β-D-glucopyranosyl-(1-4)-α-L-cymaropyranosy-(1-4)- β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside. The cytotoxic activities of the compound were evaluated using the A549 and MCF-7 cell lines, respectively. The IC50 values of the compound were 41.3 and 67.1µM, respectively. This is the first report on the isolation of seco-ring C21 steroidal glycosides from Cynanchum hancockianum.
Keywords: Cynanchum hancockianum, C21 steroids, glycoside, deoxysugars, nuclear magnetic resonance, cytotoxic activity.
Graphical Abstract
Letters in Organic Chemistry
Title:One New C21 Steroidal Glycosides from the Leaves of Cynanchum hancockianum
Volume: 16 Issue: 7
Author(s): Shubei Yu, Xixi Lin, Yi Zheng, Zheng Wu, Wei Zheng and Liman Qiao*
Affiliation:
- Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou,China
Keywords: Cynanchum hancockianum, C21 steroids, glycoside, deoxysugars, nuclear magnetic resonance, cytotoxic activity.
Abstract: C21 steroids glycosides of various deoxysugars have been emerging from genus of Cynanchum. Besides classical C21 glycosides, many C21 glycosides with seco-ring aglycones attracted the extensive attention of many researchers. We conducted a systematic chemical investigation on Cynanchum hancockianum, which led to the isolation of one new seco-ring C21 steroidal glycosides. The new compound was identified as cynaascyriogenin 3-O-β-D-glucopyranosyl-(1-4)-α-L-cymaropyranosy-(1-4)- β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside. The cytotoxic activities of the compound were evaluated using the A549 and MCF-7 cell lines, respectively. The IC50 values of the compound were 41.3 and 67.1µM, respectively. This is the first report on the isolation of seco-ring C21 steroidal glycosides from Cynanchum hancockianum.
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Cite this article as:
Yu Shubei , Lin Xixi , Zheng Yi , Wu Zheng , Zheng Wei and Qiao Liman *, One New C21 Steroidal Glycosides from the Leaves of Cynanchum hancockianum, Letters in Organic Chemistry 2019; 16 (7) . https://dx.doi.org/10.2174/1570178615666181016113531
DOI https://dx.doi.org/10.2174/1570178615666181016113531 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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