Abstract
Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.
Keywords: Benzyl alcohol, diarylmethanes, friedel crafts reactions, substituted benzyl alcohols, titanium tetrachloride, aromatic substrates.
Graphical Abstract
Current Organic Chemistry
Title:Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates
Volume: 22 Issue: 21
Author(s): Antonella Leggio*, Emilia Lucia Belsito, Alessandra Comandè, Valentina Papaianni and Angelo Liguori*
Affiliation:
- Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS),Italy
- Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS),Italy
Keywords: Benzyl alcohol, diarylmethanes, friedel crafts reactions, substituted benzyl alcohols, titanium tetrachloride, aromatic substrates.
Abstract: Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.
Export Options
About this article
Cite this article as:
Leggio Antonella*, Belsito Lucia Emilia, Comandè Alessandra, Papaianni Valentina and Liguori Angelo*, Titanium Tetrachloride-mediated Synthesis of Diarylmethanes through the Reaction of Benzyl Alcohol Derivatives with Aromatic Substrates, Current Organic Chemistry 2018; 22 (21) . https://dx.doi.org/10.2174/1385272822666181010125902
DOI https://dx.doi.org/10.2174/1385272822666181010125902 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Multiscale Imaging of Nanoparticle Drug Delivery
Current Drug Targets Upregulation of Cytoskeleton Protein and Extracellular Matrix Protein Induced by Stromal-Derived Nitric Oxide Promotes Lung Cancer Invasion and Metastasis
Current Molecular Medicine Editorial (Thematic Issue: Emerging Azoles: Structure Function Relationship and Their Therapeutic Potential)
The Natural Products Journal Editorial (Development and Routine Production of 11C- and 18F-Labelled Radiopharmaceuticals for Positron Emission Tomography)
Current Organic Chemistry Breast Cancer in Four Continents: Europe, Asia, North and South America. A Report of a Personal Training Experience
Current Women`s Health Reviews Effects of the Novel Non-Peptidyl Low Molecular Weight Radical Scavenger IAC in Different Models of Inflammation: A New Perspective in Anti-Inflammatory Therapy
Current Medicinal Chemistry Synthesis and Biological Evaluation of Some Novel Thiazolylhydrazinomethylideneferrocenes as Antimicrobial Agents
Letters in Drug Design & Discovery Factors Modulating Fibrates Response: Therapeutic Implications and Alternative Strategies
Endocrine, Metabolic & Immune Disorders - Drug Targets Analysis of miRNAs Targeting 3’UTR of H2AFX Gene: a General <i>in Silico</i> Approach
MicroRNA Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy
Current Pharmaceutical Biotechnology MicroRNAs: Emerging Role in the Endogenous μ Opioid System
CNS & Neurological Disorders - Drug Targets Significant Metabolites and Outlier-Robust Classifier Identification for Breast Cancer Prediction
Current Metabolomics The α7 Nicotinic Acetylcholine Receptor Complex: One, Two or Multiple Drug Targets?
Current Drug Targets Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target
Mini-Reviews in Medicinal Chemistry Lymphoid-Specific Tyrosine Phosphatase (Lyp): A Potential Drug Target For Treatment of Autoimmune Diseases
Current Drug Targets Challenging the Current Approaches to Multiple Myeloma-Related Bone Disease: From Bisphosphonates to Target Therapy
Current Cancer Drug Targets The Update of NGAL in Acute Kidney Injury
Current Protein & Peptide Science Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives
Letters in Drug Design & Discovery Neoadjuvant Therapy for HER2-positive Breast Cancer
Reviews on Recent Clinical Trials Targeting STAT1 in Both Cancer and Insulin Resistance Diseases
Current Protein & Peptide Science