Sam Domains in Multiple Diseases

doi:10.2174/0929867325666181009114445
摘要

背景:无菌的alpha motif (Sam)域是一个小的螺旋蛋白模块，能够发生相同或不同的低聚反应，以及聚合作用，从而形成不同类型的蛋白结构。少数Sam区域参与了病理过程，因此，它们为开发新的潜在治疗途径提供了有价值的靶点。本研究的目的是收集关于Sam区域可以促进疾病发生和进展的不同模式的最新知识。方法:这篇综述是通过检索文献建立的: a) Sam结构域的结构特性，b) Sam模块介导的相互作用，c)与特定疾病相关的蛋白质中Sam结构域的存在。结果:Sam结构域在癌症、肾脏疾病、白内障等疾病中起重要作用。通常病理与直接定位于Sam区域的突变有关，这些突变改变了它们的稳定性和/或影响了对适当的蛋白质功能至关重要的相互作用。在少数疾病中，Sam motif起到一种“侧作用”，通过增强不同蛋白域的作用来协同病理事件。结论:考虑到Sam领域在多种疾病中的作用，需要更多的努力和新的药物发现运动来发现针对Sam领域的小分子和/或多肽。这类化合物可能是构建治疗不同疾病的新策略的基础。
关键词: Sam域，药物研发，结构生物学，蛋白质的相互作用，疾病，治疗方法。
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DOI https://dx.doi.org/10.2174/0929867325666181009114445	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

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