摘要
背景:苯硼酸聚合物(PBA聚合物)作为潜在的刺激响应材料受到了广泛的关注,这些材料可用于药物递送仓库,组织工程支架,HIV屏障和生物分子检测/传感平台。 PBA聚合物的独特之处在于它们与二醇的相互作用,这导致可逆的共价键形成。硼酸和二醇之间可逆键合的这种性质对于它们在生物医学领域的应用至关重要。 方法:我们搜索了同行评审的文章,包括来自Scopus,PubMed和Google Scholar的评论,重点是1)PBA的化学,2)PBA聚合物的合成以及3)它们的生物医学应用。 结果:在这篇综述中,我们总结了约179篇论文。本综述中描述的大多数应用都集中在PBA分子与二醇分子相互作用的独特能力以及所得硼酸酯的动力学性质上。硼酸酯对周围pH的强烈敏感性也使这些分子具有刺激响应性。此外,我们还讨论了动态硼酸酯键的重新排列如何使基于PBA的材料具有其他独特功能,例如自修复和剪切稀化。 结论:PBA在聚合物链中的存在可以使其具有多种功能/相对性,而不会改变其内在特性。在这篇综述中,我们讨论了具有多种功能的PBA聚合物的开发及其生物医学应用,特别关注硼酸酯基团的动态性质。
关键词: 苯硼酸,自愈,刺激响应,可逆,水凝胶,聚合物。
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