摘要
多发性骨髓瘤(MM)以恶性血浆B淋巴细胞的克隆性增殖为特征,至今仍是一种不治之症。mm约占所有血细胞的10%。GIC癌症。其分子机制尚不清楚,但肿瘤细胞的骨髓微环境和遗传因素在这一过程中起着明显的作用。准确的诊断是很重要的。然而,要正确地识别和分层这种疾病,MM的识别步骤是费时费力的.因此,早期分子诊断方法的发展在ord中具有重要的意义。考虑到低生存率/缓解期的性质,在疾病进展中尽早开始适当的治疗。通过分析组学的分子诊断代表一个o。f有希望加快诊断过程的工具集。本文综述了高灵敏度分析组学方法(基因组学、蛋白质组学)的应用现状。、代谢组学、脂组学和糖类)在MM诊断中的分子水平。
关键词: 多发性骨髓瘤,分子诊断,基因组学,蛋白质组学,代谢组学,脂肪组学,糖类学。
Current Molecular Medicine
Title:Utilization of Analytical Omics Tools in the Molecular Diagnostics of Multiple Myeloma
Volume: 18 Issue: 4
关键词: 多发性骨髓瘤,分子诊断,基因组学,蛋白质组学,代谢组学,脂肪组学,糖类学。
摘要: Multiple myeloma (MM) is characterized by the clonal proliferation of malignant plasma B-lymphocytes and even as of today, it is an incurable disease. MM accounts for approximately 10% of all hematologic cancers. Its molecular pathogenesis is poorly understood, but the bone marrow microenvironment of tumor cells and genetic factors have apparent roles in the process. Accurate diagnosis is important to properly identify and stratify the disease, however, MM identification steps are time-consuming and expensive. Thus, development of early molecular diagnostic methods is of high importance in order to start proper therapies as early in the disease progression as possible, given the nature of the poor survival rates/remission periods. Molecular diagnostics via analytical omics represents one of the promising toolsets to speed up the diagnostic process. In this paper, we critically review the utilization of state of the art, high sensitivity analytical omics approaches (genomics, proteomics, metabolomics, lipidomics and glycomics) in MM diagnostics at the molecular level.
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Cite this article as:
Utilization of Analytical Omics Tools in the Molecular Diagnostics of Multiple Myeloma, Current Molecular Medicine 2018; 18 (4) . https://dx.doi.org/10.2174/1566524018666181008112738
DOI https://dx.doi.org/10.2174/1566524018666181008112738 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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