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Current Vascular Pharmacology

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ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

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Review Article

Extracellular Vesicles and Insulin Resistance: A Potential Interaction in Vascular Dysfunction

Author(s): Tamara Sáez*, Fernando Toledo and Luis Sobrevia*

Volume 17, Issue 5, 2019

Page: [491 - 497] Pages: 7

DOI: 10.2174/1570161116666181002095745

Price: $65

Abstract

Insulin resistance plays a key role in cardiovascular complications associated with diabetes mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors influencing the vascular insulin resistance are the extracellular vesicles. The extracellular vesicles include exosomes, microvesicles, and apoptotic bodies which are released to the circulation by different vascular cells. Since the cargo of extracellular vesicles seems to be altered in metabolic complications associated with insulin resistance, these vesicles may be candidates contributing to vascular insulin resistance. Despite the studies linking insulin resistance signalling pathways with the vascular effect of extracellular vesicles, the involvement of these structures in vascular insulin resistance is a phenomenon that remains unclear.

Keywords: Insulin, insulin resistance, endothelium, vascular, extracellular vesicles, T2DM.

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Graphical Abstract

[1]
World Health Organization. Diabetes mellitus. 2017. Available at ( https://www.who.int/health-topics/diabetes#tab=overview).
[2]
American Diabetes Association (ADA).Classification and diagnosis of diabetes: Standards of medical care in diabetes 2018. Diabetes Care 2018; 41: 13-27.
[3]
Chen L, Chen R, Wang H, Liang F. Mechanisms linking inflammation to insulin resistance. Int J Endocrinol 2015; 2015: 1-9.
[4]
Petrie JR, Guzik TJ, Touyz RM. Diabetes, hypertension, and cardiovascular disease: Clinical insights and vascular mechanisms. Can J Cardiol 2017; 34: 575-84.
[5]
Silva L, Subiabre M, Araos J, et al. Insulin/adenosine axis linked signalling. Mol Aspects Med 2017; 55: 45-61.
[6]
Sáez T, de Vos P, Sobrevia L, Faas MM. Is there a role for exosomes in foetoplacental endothelial dysfunction in gestational diabetes mellitus? Placenta 2018; 61: 48-54.
[7]
Reaven G. Insulin resistance and coronary heart disease in nondiabetic individuals. Arterioscler Thromb Vasc Biol 2012; 32: 1754-9.
[8]
Rehman K, Akash MS. Mechanisms of inflammatory responses and development of insulin resistance: How are they interlinked? J Biomed Sci 2016; 23: 87.
[9]
Cauwenberghs N, Knez J, Thijs L, et al. Relation of insulin resistance to longitudinal changes in left ventricular structure and function in a general population. J Am Heart Assoc 2018; 7e008315
[10]
Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M. Insulin resistance as a physiological defence against metabolic stress: Implications for the management of subsets of type 2 diabetes. Diabetes 2015; 64: 673-86.
[11]
Pierce GL. Targeting vascular endothelial cell insulin resistance in type 2 diabetes mellitus: Is protein kinase cβ the bullseye for reducing vascular risk in diabetes? Circulation 2013; 127: 16-8.
[12]
Salsoso R, Guzmán-Gutiérrez E, Sáez T, et al. Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia. Placenta 2015; 36: 287-96.
[13]
Sobrevia L, Salsoso R, Fuenzalida B, et al. Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus. Front Physiol 2016; 7: 1-15.
[14]
Villalobos-Labra R, Silva L, Subiabre M, et al. Akt/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy. J Diabetes Res 2017; 2017: 1-13.
[15]
Haeusler RA, McGraw TE, Accili D. Biochemical and cellular properties of insulin receptor signalling. Nat Rev Mol Cell Biol 2018; 19: 31-44.
[16]
Jung C, Shemyakin A, Böhm F, Pernow J. Endothelial microparticles in patients with insulin resistance. Diabetes Metab 2009; 35: 71-3.
[17]
Berezin AE, Kremzer AA, Cammarota G, et al. Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure. Clin Chem Lab Med 2016; 54: 1259-67.
[18]
Chiarello DI, Salsoso R, Toledo F, et al. Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia. Mol Aspects Med 2018; 60: 69-80.
[19]
Pardo F, Villalobos-Labra R, Sobrevia B, Toledo F, Sobrevia L. Extracellular vesicles in obesity and diabetes mellitus. Mol Aspects Med 2018; 60: 81-91.
[20]
Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol 2014; 6a009191
[21]
Westermeier F, Salomón C, Farías M, et al. Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium. FASEB J 2015; 29: 37-49.
[22]
Westermeier F, Sáez T, Arroyo P, et al. Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus. Diabetes Metab Res Rev 2016; 32: 350-65.
[23]
Escribano O, Beneit N, Rubio-Longás C, López-Pastor AR, Gómez-Hernández A. The role of insulin receptor isoforms in diabetes and its metabolic and vascular complications. J Diabetes Res 2017; 20171403206
[24]
Daiber A, Steven S, Weber A. Targeting vascular (endothelial) dysfunction. Br J Pharmacol 2017; 174: 1591-619.
[25]
Cabrera L, Saavedra A, Rojas S, et al. Insulin induces relaxation and decreases hydrogen peroxide-induced vasoconstriction in human placental vascular bed in a mechanism mediated by calcium-activated potassium channels and L-arginine/nitric oxide pathways. Front Physiol 2016; 7: 529.
[26]
Bian O, Zhang H, Guan Q, Sun Y, Zeng D. High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells. Mol Med Rep 2015; 12: 331-6.
[27]
Zhang BF, Jiang H, Chen J, et al. KDM3A inhibition attenuates high concentration insulin-induced vascular smooth muscle cell injury by suppressing MAPK/NF-κB pathways. Int J Mol Med 2018; 41: 1265-74.
[28]
Rask-Madsen C, Kahn CR. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2012; 32: 2052-9.
[29]
Wang X, Lockhart SM, Rathjen T, et al. Insulin downregulates the transcriptional coregulator CITED2, an inhibitor of proangiogenic function in endothelial cells. Diabetes 2016; 65: 3680-90.
[30]
Mahmoud AM, Szczurek MR, Blackburn BK, et al. Hyperinsulinemia augments endothelin-1 protein expression and impairs vasodilation of human skeletal muscle arterioles. Physiol Rep 2016; 4e12895
[31]
Kou H, Deng J, Gao D, et al. Relationship among adiponectin, insulin resistance and atherosclerosis in non-diabetic hypertensive patients and healthy adults. Clin Exp Hypertens 2018; 16: 1-8.
[32]
Hou Z, Hu Y, Yang X, Chen W. Antihypertensive effects of Tartary buckwheat flavonoids by improvement of vascular insulin sensitivity in spontaneously hypertensive rats. Food Funct 2017; 8: 4217-28.
[33]
Trammell AW, Talati M, Blackwell TR, et al. Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension. Pulm Circ 2017; 7: 624-34.
[34]
Khaliq OP, Murugesan S, Moodley J, Mackraj I. Differential expression of miRNAs are associated with the insulin signaling pathway in preeclampsia and gestational hypertension. Clin Exp Hypertens 2018; 30: 1-8.
[35]
Kayemba-Kay’s S, Peters C, Geary MP, et al. Maternal hyperinsulinism and glycaemic status in the first trimester of pregnancy are associated with the development of pregnancy-induced hypertension and gestational diabetes. Eur J Endocrinol 2013; 168: 413-8.
[36]
Salsoso R, Farías M, Gutiérrez J, et al. Adenosine and preeclampsia. Mol Aspects Med 2017; 55: 126-39.
[37]
Westermeier F, Salomón C, González M, et al. Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium. Diabetes 2011; 60: 1677-87.
[38]
Salomón C, Westermeier F, Puebla C, et al. Gestational diabetes reduces adenosine transport in human placental microvascular endothelium, an effect reversed by insulin. PLoS One 2012; 7e40578
[39]
Beneit N, Fernández-García CE, Martín-Ventura JL, et al. Expression of Insulin Receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis. Cardiovasc Diabetol 2016; 15: 161.
[40]
Sáez T, Salsoso R, Leiva A, et al. Human umbilical vein endothelium-derived exosomes play a role in foetoplacental endothelial dysfunction in gestational diabetes mellitus. Biochim Biophys Acta 2018; 1864: 499-508.
[41]
Raposo G, Stoorvogel W. Extracellular vesicles: Exosomes, microvesicles, and friends. J Cell Biol 2013; 200: 373-83.
[42]
Müller G. Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab Syndr Obes 2012; 5: 247-82.
[43]
Eguchi A, Lazic M, Armando AM, et al. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl) 2016; 94: 1241-53.
[44]
Martínez MC, Andriantsitohaina R. Extracellular vesicles in metabolic syndrome. Circ Res 2017; 120: 1674-86.
[45]
Ju R, Zhuang ZW, Zhang J, et al. Angiopoietin-2 secretion by endothelial cell exosomes: Regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial Nitric Oxide Synthase (eNOS) and syndecan-4/syntenin pathways. J Biol Chem 2014; 289: 510-9.
[46]
Sedrakyan S, Villani V, Da Sacco S, et al. Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage. Sci Rep 2017; 7: 16875.
[47]
Tong M, Stanley JL, Chen Q, et al. Placental nano-vesicles target to specific organs and modulate vascular tone in vivo. Hum Reprod 2017; 32: 2188-98.
[48]
Su SA, Xie Y, Fu Z, et al. Emerging role of exosome-mediated intercellular communication in vascular remodeling. Oncotarget 2017; 8: 25700-12.
[49]
Freed JK, Durand MJ, Hoffmann BR, et al. Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. Am J Physiol 2017; 312: 1096-104.
[50]
Motta-Mejia C, Kandzija N, Zhang W, et al. Placental vesicles carry active endothelial nitric oxide synthase and their activity is reduced in preeclampsia. Hypertension 2017; 70: 372-81.
[51]
Jia L, Fan J, Cui W, et al. Endothelial cell-derived microparticles from patients with obstructive sleep apnea hypoxia syndrome and coronary artery disease increase aortic endothelial cell dysfunction. Cell Physiol Biochem 2017; 43: 2562-70.
[52]
Burger D, Turner M, Munkonda MN, Touyz RM. Endothelial microparticle-derived reactive oxygen species: Role in endothelial signaling and vascular function. Oxid Med Cell Longev 2016; 20165047954
[53]
Royo F, Moreno L, Mleczko J, et al. Hepatocyte-secreted extracellular vesicles modify blood metabolome and endothelial function by an arginase-dependent mechanism. Sci Rep 2017; 7: 42798.
[54]
de la Cuesta F, Baldan-Martin M, Moreno-Luna R, et al. Kalirin and CHD7: Novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria. Oncotarget 2017; 8: 15553-62.
[55]
Viegas CSB, Santos L, Macedo AL, et al. Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: A role for GRP (Gla-Rich Protein). Arterioscler Thromb Vasc Biol 2018; 38: 575-87.
[56]
Li S, Wei J, Zhang C, et al. Cell-derived microparticles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Cell Physiol Biochem 2016; 39: 2439-50.
[57]
Gündüz Z, Dursun İ, Tülpar S, et al. Increased endothelial microparticles in obese and overweight children. J Pediatr Endocrinol Metab 2012; 25: 1111-7.
[58]
Agouni A, Lagrue-Lak-Hal AH, Ducluzeau PH, et al. Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. Am J Pathol 2008; 173: 1210-9.
[59]
Campello E, Zabeo E, Radu CM, et al. Dynamics of circulating microparticles in obesity after weight loss. Intern Emerg Med 2016; 11: 695-702.
[60]
Liem M, Ang CS, Mathivanan S. Insulin mediated activation of PI3K/Akt signalling pathway modifies the proteomic cargo of extracellular vesicles. Proteomics 2017; 17: 23-4.
[61]
Taguchi K, Hida M, Narimatsu H, Matsumoto T, Kobayashi T. Glucose and angiotensin II-derived endothelial extracellular vesicles regulate endothelial dysfunction via ERK1/2 activation. Pflugers Arch 2017; 469: 293-302.
[62]
Kranendonk ME, Visseren FL, van Herwaarden JA, et al. Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells. Obesity (Silver Spring) 2014; 22: 2216-23.
[63]
Benedict C, Grillo CA. Insulin resistance as a therapeutic target in the treatment of alzheimer’s disease: A state-of-the-art review. Front Neurosci 2018; 12: 215.
[64]
Kapogiannis D, Boxer A, Schwartz JB, et al. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease. FASEB J 2015; 29: 589-96.
[65]
Jansen F, Wang H, Przybilla D, et al. Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus. Cardiovasc Diabetol 2016; 15: 49.
[66]
Zhang J, Du YY, Lin YF, et al. The cell growth suppressor, mir-126, targets IRS-1. Biochem Biophys Res Commun 2008; 377: 136-40.
[67]
Wang C, Li F, Guo J, et al. Insulin resistance, blood glucose and inflammatory cytokine levels are risk factors for cardiovascular events in diabetic patients complicated with coronary heart disease. Exp Ther Med 2018; 15: 1515-9.
[68]
Bersch-Ferreira ÂC, Sampaio GR, Gehringer MO, et al. Association between plasma fatty acids and inflammatory markers in patients with and without insulin resistance and in secondary prevention of cardiovascular disease, a cross-sectional study. Nutr J 2018; 17: 26.
[69]
Tang N, Sun B, Gupta A, Rempel H, Pulliam L. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells. FASEB J 2016; 30: 3097-106.
[70]
Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009; 78: 539-52.

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