Effect of Diterpenes on Hepatic System

Title:Effect of Diterpenes on Hepatic System

Volume: 24 Issue: 35

Author(s): Márcia F.C.J. Paz, Muhammad T. Islam, Shams Tabrez*, Chelapram K. Firoz, Nasimudeen R. Jabir, Mohammad A. Kamal, Ana A.C. Melo-Cavalcante and Fernanda R.C. Almeida

Affiliation:

• King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589,Saudi Arabia

Keywords: Diterpenes, hepatoprotective, hepatotoxic, liver, hepatic system, antioxidant.

Abstract: Complication in the hepatic system is a major concern for human being. To control and keep the hepatic system healthy, a number of measures, including drug treatments are considered. Diterpenes are essential oils having promising antioxidant and cytotoxic properties along with their genotoxic and mutagenic effects. These agents are good targets for health promotion, especially in the light of their potential organo-protectivity. We searched in the databases, PUBMED and SCIENCE DIRECT from June 2011 to June 2016 for publishing evidence on diterpenes and their effects on hepatic system. After sorting the data, activity-wise findings are discussed in this current article. The results suggest that diterpenes have hepatoprotectivity property via antioxidant and anti-inflammatory, antimicrobial, anticancer/antitumor, hypolipidemic, anti-apoptosis, autophagic, antimetastasize, anti-proliferating, anti-fibrosis as well as receptor and serum biomarkers mediated pathways. On the other hand, hepatoxic effects of diterpenes are also accounted with cytotoxicity, apoptotic cell death and downregulation of cytochrome P450 systems. A number of important diterpenes have been reported in the literatures that act on the hepatic system. Some of them exert toxic effects on the liver, especially in rodent model. Hence, more extensive researches are recommended that will highlight their mechanism of action on the liver.

Cite this article as:

Paz F.C.J. Márcia , Islam T. Muhammad , Tabrez Shams *, Firoz K. Chelapram , Jabir R. Nasimudeen , Kamal A. Mohammad , Melo-Cavalcante A.C. Ana and Almeida R.C. Fernanda , Effect of Diterpenes on Hepatic System, Current Pharmaceutical Design 2018; 24 (35) . https://dx.doi.org/10.2174/1381612824666181001152247