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General Review Article

Omega-3多不饱和脂肪酸衍生的脂质介体及其在药物发现中的应用

卷 27, 期 10, 2020

页: [1670 - 1689] 页: 20

弟呕挨: 10.2174/0929867325666180927100120

价格: $65

摘要

Omega-3（n-3）和omega-6（n-6）多不饱和脂肪酸（PUFA）在健康和病理状况中起着至关重要的作用，并且常常是相反的调节作用。 n-3和n-6 PUFA经历了生物转化，成为一系列平行的脂质介体，它们是许多细胞过程的有效调节剂。源自n-6 PUFA的脂质介体具有广泛的生物学作用，这些介体已成为许多临床批准药物（包括世界卫生组织列出的拉坦前列素（Xalatan：辉瑞））开发中的先导化合物。它被列为世卫组织基本药物模型清单。 n-3 PUFA衍生的介体受到的关注较少，部分原因是早期研究表明n-3 PUFA只是作为生物转化酶的竞争底物，并减少了n-6 PUFA衍生的脂质介体的形成。但是，最近的研究表明，n-3 PUFA衍生的介体本身具有生物学上的重要意义。现在正在出现，许多n-3 PUFA衍生的脂质介体具有与n-6对应物不同的有效且多样的活性。这些发现为药物发现提供了新的机会。在这里，我们审查了n-3 PUFA衍生的脂质介体的生物合成，并强调了其可用于药物开发的生物学作用。最后，我们提供了药物化学研究的实例，该实例利用了n-3 PUFA衍生的脂质介体作为药物设计中的新型先导化合物。

关键词: 多不饱和脂肪酸，脂质介体，脂蛋白，omega-3，生物转化，药物设计策略。

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