摘要
乳腺癌仍然是妇女死亡的主要原因。虽然在早期阶段,局限性乳腺癌是很容易治疗的;然而,晚期疾病的死亡率仍然很高。治疗成功率的差异突出表明,目前的治疗方法不足以治疗晚期乳腺癌.随着人们寻求新的和改进的治疗方法,一种治疗方法得到了相当多的关注。肿瘤病毒具有独特的能力,可以通过固有的或工程的手段来攻击癌细胞。它们以多种形式出现,主要来自巴尔的摩分类系统定义的四个主要病毒组。这些载体可以靶向和杀死癌细胞,甚至刺激患者的免疫治疗效果。本文不仅讨论了乳腺癌治疗中所追求的单个肿瘤病毒,而且还讨论了与现有或新的治疗方法相结合的联合疗法的出现,这已成为治疗乳腺癌的一种特别有前途的策略。总之,肿瘤性病毒治疗是提高晚期乳腺癌治疗效果的一种有希望的策略,因此为患者的个性化治疗提供了一个独特的平台。
关键词: 乳腺癌,临床试验,肿瘤,临床前,载体,病毒治疗。
Current Gene Therapy
Title:Oncolytic Virotherapy for Breast Cancer Treatment
Volume: 18 Issue: 4
关键词: 乳腺癌,临床试验,肿瘤,临床前,载体,病毒治疗。
摘要: Breast cancer continues to be a leading cause of mortality among women. While at an early stage, localized breast cancer is easily treated; however, advanced stages of disease continue to carry a high mortality rate. The discrepancy in treatment success highlights that current treatments are insufficient to treat advanced-stage breast cancer. As new and improved treatments have been sought, one therapeutic approach has gained considerable attention. Oncolytic viruses are uniquely capable of targeting cancer cells through intrinsic or engineered means. They come in many forms, mainly from four major virus groups as defined by the Baltimore classification system. These vectors can target and kill cancer cells, and even stimulate immunotherapeutic effects in patients. This review discusses not only individual oncolytic viruses pursued in the context of breast cancer treatment but also the emergence of combination therapies with current or new therapies, which has become a particularly promising strategy for treatment of breast cancer. Overall, oncolytic virotherapy is a promising strategy for increased treatment efficacy for advanced breast cancer and consequently provides a unique platform for personalized treatments in patients.
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Oncolytic Virotherapy for Breast Cancer Treatment, Current Gene Therapy 2018; 18 (4) . https://dx.doi.org/10.2174/1566523218666180910163805
DOI https://dx.doi.org/10.2174/1566523218666180910163805 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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