Investigation of the Inhibitory Effects of Human Carbonic Anhydrase I and Jack Bean Urease by Coumarin Derivates

Title:Investigation of the Inhibitory Effects of Human Carbonic Anhydrase I and Jack Bean Urease by Coumarin Derivates

Volume: 14 Issue: 3

Author(s): Imdat Aygul, Fatma Yaylaci Karahalil*, Ozkan Danis, Ayşe Ogan and Sevgi Kolayli

Affiliation:

• Department of Chemistry and Chemical Processing Technologies, Biochemistry Programme, Maçka Vocational School, Karadeniz Technical University, Trabzon,Turkey

Keywords: Carbonic anhydrase, coumarin, inhibition, jack bean, synthesis compounds, urease.

Abstract: Introduction: This study investigated the in vitro inhibition properties of newly synthesized coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease. Activities were expressed as IC50 (mg/mL), the concentration reducing 50% of the enzymes. The IC50 values for hCA-I ranged 5.20 µM from 12.10 µM, with compound C3 exhibiting the highest activity. The inhibition values for urease ranged 22.30 µM to 39.00 µM, the highest activity being observed in C5.

Conclusion: Comparing the inhibitions with standard inhibitors of the enzymes, while the samples exhibited moderate inhibitions against hCA I, high inhibition was determined against urease.

Cite this article as:

Aygul Imdat, Karahalil Yaylaci Fatma*, Danis Ozkan, Ogan Ayşe and Kolayli Sevgi, Investigation of the Inhibitory Effects of Human Carbonic Anhydrase I and Jack Bean Urease by Coumarin Derivates, Current Enzyme Inhibition 2018; 14 (3) . https://dx.doi.org/10.2174/1573408014666180903143132

DOI https://dx.doi.org/10.2174/1573408014666180903143132	Print ISSN 1573-4080
Publisher Name Bentham Science Publisher	Online ISSN 1875-6662