Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility

Title:Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility

Volume: 18 Issue: 14

Author(s): V. Lenin Maruthanila, Ramakrishnan Elancheran*, Ajaikumar B. Kunnumakkar, Senthamaraikannan Kabilan and Jibon Kotoky*

Affiliation:

• Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam,India

• National Institute of Pharmaceutical Education and Research, Guwahati-781032, Assam,India

Keywords: Mahanine, girinimbine, Murraya species, prevention and therapy, apoptosis, pleiotropic anticancer.

Abstract: Emerging evidence present credible support in favour of the potential role of mahanine and girinimbine. Non-toxic herbal carbazole alkaloids occur in the edible part of Murraya koenigii, Micromelum minutum, M. zeylanicum, and M. euchrestiolia. Mahanine and girinimbine are the major potent compounds from these species. In fact, they interfered with tumour expansion and metastasis development through down-regulation of apoptotic and antiapoptotic protein, also involved in the stimulation of cell cycle arrest. Consequently, these compounds were well proven for the in-vitro and in vivo evaluation that could be developed as novel agents either alone or as an adjuvant to conventional therapeutics. Therefore, mahanine and girinimbine analogs have the potential to be the promising chemopreventive agents for the tumour recurrence and the treatment of human malignancies. In this review, an updated wide-range of pleiotropic anticancer and biological effects induction by mahanine and girinimbine against cancer cells were deeply summarized.

Cite this article as:

Maruthanila Lenin V., Elancheran Ramakrishnan*, Kunnumakkar B. Ajaikumar, Kabilan Senthamaraikannan and Kotoky Jibon *, Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (14) . https://dx.doi.org/10.2174/1871520618666180830151720