Abstract
Background: The problem of poor immunogenicity of new generation vaccines has generated the need for more effective and safe adjuvants for inducing a seroprotective immune response.
Objective and Method: The plant-based immunoadjuvants have the potential to promote an optimized immune response and are promising candidate adjuvants for novel vaccine development. There are many natural compounds, which exhibit vaccine adjuvant activity. However, safety and hemolytic toxicity remain a problem. Research in the last four decades shows that plant extracts can be screened for isolating the least toxic adjuvant. Plant-based adjuvants with their superior immunostimulatory property could provide us with an effective alternative to conventional adjuvants.
Conclusion: The present paper enumerates the plant-based immunoadjuvant which has shown remarkable immunostimulatory properties.
Keywords: Haemolytic, immunoadjuvant, ovalbumin, polysaccharide, saponins, splenocyte.
Graphical Abstract
Current Traditional Medicine
Title:Plant-based Adjuvant in Vaccine Immunogenicity: A Review
Volume: 4 Issue: 3
Author(s): P.K. Lakshmi, Shweta Kumar, Sulakshhna Pawar, M.S. Sudheesh and Rajesh Singh Pawar*
Affiliation:
- Truba Institute of Pharmacy, Karod-Gandhi Nagar, By Pass Road, Bhopal, 462038,India
Keywords: Haemolytic, immunoadjuvant, ovalbumin, polysaccharide, saponins, splenocyte.
Abstract: Background: The problem of poor immunogenicity of new generation vaccines has generated the need for more effective and safe adjuvants for inducing a seroprotective immune response.
Objective and Method: The plant-based immunoadjuvants have the potential to promote an optimized immune response and are promising candidate adjuvants for novel vaccine development. There are many natural compounds, which exhibit vaccine adjuvant activity. However, safety and hemolytic toxicity remain a problem. Research in the last four decades shows that plant extracts can be screened for isolating the least toxic adjuvant. Plant-based adjuvants with their superior immunostimulatory property could provide us with an effective alternative to conventional adjuvants.
Conclusion: The present paper enumerates the plant-based immunoadjuvant which has shown remarkable immunostimulatory properties.
Export Options
About this article
Cite this article as:
Lakshmi P.K. , Kumar Shweta , Pawar Sulakshhna , Sudheesh M.S. and Pawar Singh Rajesh *, Plant-based Adjuvant in Vaccine Immunogenicity: A Review, Current Traditional Medicine 2018; 4 (3) . https://dx.doi.org/10.2174/2215083804666180830142648
DOI https://dx.doi.org/10.2174/2215083804666180830142648 |
Print ISSN 2215-0838 |
Publisher Name Bentham Science Publisher |
Online ISSN 2215-0846 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecular Classification and Drug Response Prediction in Cancer
Current Drug Targets Platinum Compounds: A Hope for Future Cancer Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Inventions Designed to Enhance Drug Delivery Across Epithelial and Endothelial Cells Through the Paracellular Pathway
Recent Patents on Drug Delivery & Formulation Cancer-Associated Carbonic Anhydrases and Their Inhibition
Current Pharmaceutical Design Aspirin Use on Incidence and Mortality of Gastrointestinal Cancers: Current State of Epidemiological Evidence
Current Pharmaceutical Design Conjugation of Phthalocyanine Photosensitizer with Poly(amidoamine) Dendrimer: Improved Solubility, Disaggregation and Photoactivity Against HepG2 Cells
Current Cancer Drug Targets Traditional Chinese Medicines (TCMs) for Molecular Targeted Therapies of Tumours
Current Drug Discovery Technologies Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review
Anti-Cancer Agents in Medicinal Chemistry Intercellular Crosstalk Via Extracellular Vesicles in Tumor Milieu as Emerging Therapies for Cancer Progression
Current Pharmaceutical Design Effect of PUFAs Oral Administration on the Amount of Apoptotic Caspases Enzymes in Gastric Cancer Patients Undergoing Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Glutamine, Glucose and other Fuels for Cancer
Current Pharmaceutical Design Reactivity-Based Drug Discovery Using Vitamin B6-Derived Pharmacophores
Mini-Reviews in Medicinal Chemistry Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Ring Finger Ubiquitin Protein Ligases and Their Implication to the Pathogenesis of Human Diseases
Current Pharmaceutical Design How Targeted Therapy Influence Renal Surgery for Renal Cell Carcinoma
Current Drug Targets Pharmacokinetics-Pharmacology Disconnection of Herbal Medicines and its Potential Solutions with Cellular Pharmacokinetic-Pharmacodynamic Strategy
Current Drug Metabolism Anti-cancer Nitrogen-Containing Heterocyclic Compounds
Current Organic Chemistry The Effect of Tumour Necrosis Factor-α on Periodontal Ligament Stem Cell Differentiation and the Related Signaling Pathways
Current Stem Cell Research & Therapy Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs
Current Medicinal Chemistry NONO-TFE3 Fusion Promotes Aerobic Glycolysis and Angiogenesis by Targeting <i>HIF1A</i> in <i>NONO-TFE3</i> Translocation Renal Cell Carcinoma
Current Cancer Drug Targets