摘要
背景：空气污染是哮喘急性发作的主要原因。大多数研究表明，暴露于粗颗粒物质和细颗粒物质与哮喘急性发作有关。超细颗粒（UFP，空气动力学直径≤0.1μm）是最小的空气传播颗粒，能够深入肺部。毒理学研究表明，暴露于UFP可能对呼吸系统健康产生严重影响。然而，关于UFP暴露对儿童哮喘急性发作影响的流行病学证据仍不清楚。 目的：我们进行了一项荟萃分析，以定量评估接触UFPs对儿童哮喘急性发作的影响。 方法：我们搜索了四个数据库进行流行病学研究，直到2018年3月20日。使用固定效应模型估算每10000颗粒/ cm3的汇集比值比（OR）和95％置信区间（95％CI）。还进行了亚组分析，敏感性分析以及Begg和Egger的回归。 结果：8项中高质量研究共计51542项事件符合纳入标准。暴露于UFPs显示与儿童哮喘急性发作呈正相关[OR（95％CI）：1.070（1.037,1.104）]，哮喘相关急诊科就诊增加[OR（95％CI）：1.111（1.055,1.170）]，和哮喘相关的住院[OR（95％CI）：1.045（1.004,1.088）]并且与长期滞后的儿童哮喘急性发作有更强的关联[OR（95％CI）：1.060（1.039,1.082）]。检测到低异质性和无发表偏倚。 结论：暴露于UFP可能会增加哮喘急性发作的风险，并可能与长期滞后的儿童哮喘急性发作密切相关。
关键词: 超细颗粒，哮喘，儿童，荟萃分析，暴露，危险因素。
图形摘要
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