Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy

Title:Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy

Volume: 18 Issue: 14

Author(s): Carolina Anazco*, Armando Rojas, Ileana Gonzalez, Maite A. Castro, Paz Robert and Felipe Oyarzun-Ampuero*

Affiliation:

• Departamento de Ciencias Pre- Clínicas, Laboratorio de Investigaciones Biomedicas, Facultad de Medicina, Universidad Catolica del Maule, Av. San Miguel 3605, Talca 3480112,Chile

• Departamento de Ciencias y Tecnología Farmaceuticas, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494,Chile

Keywords: Polyphenols, Flavonoids, Lysyl Oxidase, Basement membrane, Collagen, Skin, Aging, Extracellular matrix, Dermis, Encapsulation.

Abstract: Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance of that tissue. Lysyl oxidases, also known as LOX enzymes, are the major collagen cross-linking enzymes that play a pivotal role in homeostasis. This minireview summarizes evidence that describes an amino oxidase-like activity, which could be attributed to polyphenols, or where polyphenols could be required. We also discuss some available collagen formulations and the scientific evidence that describes the impact on dermal extracellular matrix. In addition, information about encapsulation strategies to carry polyphenols, and some examples are also provided.

Cite this article as:

Anazco Carolina *, Rojas Armando, Gonzalez Ileana , Castro A. Maite, Robert Paz and Oyarzun-Ampuero Felipe *, Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy, Current Topics in Medicinal Chemistry 2018; 18 (14) . https://dx.doi.org/10.2174/1568026618666180810143730