摘要
在研究皮脂腺的生理和生物化学以及影响皮肤这一成分的几种疾病方面,已经取得了相当大的进展。在这些疾病中,痤疮特别重要。它与青春期有关,由于这一阶段发生的荷尔蒙变化,当病情严重时,会导致抑郁症。此外,在相当大比例的痤疮患者,无论是青少年和成年人,它可以产生肿瘤和皮脂腺变形。这严重影响了患者的职业活动,因为他们不想在公众场合露面。本文将对皮脂腺经典研究中的几个重要问题进行综述,以报告目前这些腺体病理治疗的最新进展。皮脂腺是一个内分泌器官,能够合成和代谢不同的类固醇激素。将分析与皮肤这些过程有关的每一种酶的作用。由于皮脂腺在不同年龄的脂肪发生中的作用,在科学文献中也将对不同激素受体的存在进行综述。我们还描述了雄激素和孕激素的作用机制,它们与在这个腺体中参与脂肪生成的共同调节因子有关。我们提出了几种新的甾体化合物,其作用机制是阻止皮脂腺的脂肪生成。这些分子为皮肤病的治疗提供了新的选择。
关键词: 皮脂腺,侧腹腺,类固醇生成,雄激素,雌激素,孕激素,抗雄激素,抗孕激素,左炔诺孕酮,孕烷衍生物
图形摘要
Current Drug Targets
Title:Molecular Interactions of Different Steroids Contributing to Sebum Production. Review
Volume: 19 Issue: 15
关键词: 皮脂腺,侧腹腺,类固醇生成,雄激素,雌激素,孕激素,抗雄激素,抗孕激素,左炔诺孕酮,孕烷衍生物
摘要: Considerable progress has been made in learning about the physiology and biochemistry of the sebaceous glands and several of the diseases that affect this component of the skin. Of these diseases, acne has particular importance. It is associated with adolescence, and because of the hormonal changes that take place in this stage, when it is severe it can cause depression. Moreover, in a considerable proportion of acne sufferers both adolescent and adult, it can produce tumors and deformation of the sebaceous glands. This seriously affects the sufferers to the point where it may limit their professional activities because they do not want to be seen in public.
Several important issues from classic studies on the sebaceous gland will be reviewed in this document to report the state of the art of current treatments for the pathology of these glands.
The sebaceous gland is an intracrine organ, capable of synthesizing and metabolizing different steroidal hormones. The role of each of the enzymes involved in these processes of the skin will be analyzed. The presence of different hormone receptors in the scientific literature will be also reviewed, due to the role of the sebaceous gland in lipogenesis at different ages. We also describe the mechanism of action of androgens and progestins in relation to coregulators recruited for lipogenesis in this gland.
We propose several new steroidal compounds based on their mechanism of action to block lipogenesis in the sebaceous glands. These molecules offer potential for new treatment options for skin diseases.
Export Options
About this article
Cite this article as:
Molecular Interactions of Different Steroids Contributing to Sebum Production. Review, Current Drug Targets 2018; 19 (15) . https://dx.doi.org/10.2174/1389450119666180808113951
DOI https://dx.doi.org/10.2174/1389450119666180808113951 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Metabolic Functions of Myostatin and GDF11
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) A Sequential Ensemble Model for Communicable Disease Forecasting
Current Bioinformatics Integrating In Vitro Kinetic Data from Compounds Exhibiting Induction, Reversible Inhibition and Mechanism-Based Inactivation: In Vitro Study Design
Current Drug Metabolism A Non-Steroidal Anti-Inflammatory Agent Provides Significant Protection During Focal Ischemic Stroke with Decreased Expression of Matrix Metalloproteinases
Current Neurovascular Research Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease
Current Alzheimer Research Supportive-Expressive (SE) Psychotherapy: An Update
Current Psychiatry Reviews Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
Current Alzheimer Research Predictors of Non-adherence to Methadone Maintenance Treatment in Opioiddependent Individuals: Implications for Clinicians
Current Pharmaceutical Design ADAM19/Adamalysin 19 Structure, Function, and Role as a Putative Target in Tumors and Inflammatory Diseases
Current Pharmaceutical Design Neurobehavioral and Cognitive Changes Induced by Sleep Deprivation in Healthy Volunteers
CNS & Neurological Disorders - Drug Targets Wii-Workouts on Chronic Pain, Physical Capabilities and Mood of Older Women: A Randomized Controlled Double Blind Trial
CNS & Neurological Disorders - Drug Targets Coenzyme Q10 and Neurological Diseases: An Update
Letters in Drug Design & Discovery Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature
Current Medicinal Chemistry Compacting Proteins: Pros and Cons of Osmolyte-Induced Folding
Current Protein & Peptide Science Biomedical Consequences of Alcohol Use Disorders in the HIV-Infected Host
Current HIV Research Development of Privileged Groebke-Blackburn-Type 4-(3-aminoimidazo [1,2-a]pyridin-2-yl)benzoic Acid Core into a Combinatorial Library on Solid Phase
Letters in Organic Chemistry Optimal Sedation for the Ventilation of Critically Ill Patients
Current Respiratory Medicine Reviews Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801
Current Molecular Medicine Breakthrough Pain-Novel Analgesics
Current Clinical Pharmacology Role of Redox Homeostasis and Inflammation in the Pathogenesis of Pulmonary Arterial Hypertension
Current Medicinal Chemistry