Abstract
Background: In the recent times, organo-nano catalysis has emerged as a growing field in catalytic science with widespread applications in organic synthesis. In the present article, we have focused on the preparation of an organo-nano catalyst and its application in the synthesis of pyranopyrazole derivatives.
Method: The catalyst was fabricated by the functionalization of vitamin B1 on silica coated ferrite (Fe2O3@SiO2) nanoparticles and was characterized by different analytical techniques viz., FT-IR, TGA, TEM, SEM, EDX, VSM and powder XRD. This organo-nano catalyst was employed for the one-pot synthesis of pyranopyrazole derivatives from aromatic aldehyde / isatin, malononitrile, hydrazine hydrate and ethyl acetoacetate in water-ethanol mixture at room temperature stirring condtion.
Results: A library of pyranopyrazole derivatives was synthesized by using a simple, efficient and environmentally benign protocol. The products obtained were pure with considerably higher yields (87- 98%). The catalyst was easily retrieved from the reaction mixture and reused up to six runs without any significant decrease in its catalytic activity.
Conculsion: A simple eco-friendly method, mild reaction conditions, high product yields, short reaction times, easy catalyst recovery and recyclability make this synthetic approach an efficient and sustainable protocol.
Keywords: Condensation reaction, heterocylces, heterogeneous catalysis, magnetic nanoparticles, one pot multicomponent reaction, organo-nano catalyst, pyranopyrazoles, recyclability.
Graphical Abstract
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