摘要
虽然多酚可能对多潜能干细胞有重要作用，使其作为潜在的抗肿瘤药物值得注意，但它们对干细胞的作用可能预示着其他健康益处，如心血管和神经认知障碍的治疗。白藜芦醇是研究最多的多酚，已被发现能够使干细胞分化为心肌细胞、神经元、骨细胞和胰腺β细胞，并促进干细胞种群的增加和保护他们免受毒性损伤。姜黄素保护间充质干细胞免受毒性作用，并防止它们促进软骨细胞肥大。槲皮素使骨细胞和胰腺β细胞分化，保护神经干细胞免受损伤。表没食子酸儿茶素能防止骨细胞前体的损伤，并避免分化成不需要的脂肪细胞。金雀花碱促进成骨，同时阻止脂肪生成。其他几种多酚，大豆苷、咖啡酸和绿原酸、山奈酚和苦杏仁醇，保护干细胞免受活性氧的影响，促进干细胞分化，使其远离脂肪细胞，向骨细胞系分化。进一步的研究应该更好地阐明每一种多酚的药代动力学特征，探索新的传递系统，并将研究扩展到啮齿动物模型以外的其他物种。
关键词: 多酚干细胞，白藜芦醇，槲皮素，染料木素，表没食子酸儿茶素，骨细胞谱系。
图形摘要
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