Abstract
The occurrence of epidemic avian influenza (EAI) not only hinders the development of a country's agricultural economy, but also seriously affects human beings’ life. Recently, the information collected from Google Trends has been increasingly used to predict various epidemics. In this study, using the relevant keywords in Google Trends as well as the multiple linear regression approach, a model was developed to predict the occurrence of epidemic avian influenza. It was demonstrated by rigorous cross-validations that the success rates achieved by the new model were quite high, indicating the predictor will become a very useful tool for hospitals and health providers.
Keywords: Google trends, H5N2, avian influenza, prediction model, multiple line regression model, Chou’s intuitive metrics.
Graphical Abstract
(b)Nonthabenjawan, N.; Cardona, C.; Amonsin, A.; Sreevatsan, S. Virol. J., 2016, 13(1), 147.
(c)Pielak, R.M.; Schnell, J.R.; Chou, J.J. Proc. Natl. Acad. Sci. USA, 2009, 106(18), 7379-7384.
(d)Wang, J.; Pielak, R.M.; McClintock, M.A.; Chou, J.J. Nat. Struct. Mol. Biol., 2009, 16(12), 1267-1271.
(b)Du, Q-S.; Huang, R-B.; Wang, S-Q.; Chou, K-C. PLoS One, 2010, 5(2), e9388.
(c)Du, Q-S.; Wang, S-Q.; Huang, R-B.; Chou, K-C. Chem. Phys. Lett., 2010, 485(1), 191-195.
(d)Li, X.B.; Wang, S.Q.; Xu, W.R.; Wang, R.L.; Chou, K.C. PLoS One, 2011, 6(11), e28111.
(e)Pielak, R.M.; Chou, J.J. J. Am. Chem. Soc., 2010, 132(50), 17695-17697.
(f)Wang, S-Q.; Cheng, X-C.; Dong, W-L.; Wang, R-L.; Chou, K-C. Biochem. Biophys. Res. Commun., 2010, 401(2), 188-191.
(g)Wang, S-Q.; Du, Q-S.; Chou, K-C. Biochem. Biophys. Res. Commun., 2007, 354(3), 634-640.
(h)Wei, D-Q.; Du, Q-S.; Sun, H.; Chou, K-C. Biochem. Biophys. Res. Commun., 2006, 344(3), 1048-1055.
(i)Yu, Y.; Li, X.; Hao, P.; Wang, J-F.; Chou, K-C. Curr. Drug Metab., 2014, 15(5), 526-534.
(b)Chou, K-C. Curr. Top. Med. Chem., 2017, 17(21), 2337-2358.
(b)Manavalan, B.; Shin, T.H.; Lee, G. Oncotarget, 2017, 9(2), 1944-1956.
(c)Manavalan, B.; Basith, S.; Shin, T.H.; Choi, S.; Kim, M.O.; Lee, G. Oncotarget, 2017, 8(44), 77121-77136.
(d)Manavalan, B.; Shin, T.H.; Lee, G. Front. Microbiol., 2018, 9, 476.
(e)Manavalan, B.; Lee, J. Bioinformatics, 2017, 33(16), 2496-2503.
(f)Liu, B.; Yang, F.; Huang, D-S.; Chou, K-C. iPromoter-2L: a two-layer predictor for identifying promoters and their types by multi-window-based PseKNC. Bioinformatics, 2017.
(g)Liu, L-M.; Xu, Y.; Chou, K-C. Med. Chem., 2017, 13(6), 552-559.
(h)Qiu, W.R.; Jiang, S.Y.; Sun, B.Q.; Xiao, X.; Cheng, X.; Chou, K.C. Med. Chem., 2017, 13(8), 734-743.
(i)Xiao, X.; Cheng, X.; Su, S.; Mao, Q.; Chou, K-C. Nat. Sci., 2017, 9(09), 330.
(j)Xu, Y.; Wang, Z.; Li, C.; Chou, K-C. Med. Chem., 2017, 13(6), 544-551.
(k)Cheng, X.; Xiao, X.; Chou, K.-C. Genomics, 2017, S0888-7543(17)30102-7
(l)Khan, M.; Hayat, M.; Khan, S.A.; Iqbal, N. J. Theor. Biol., 2017, 415, 13-19.
(m)Cheng, X.; Zhao, S-G.; Lin, W-Z.; Xiao, X.; Chou, K-C. pLoc-mAnimal: predict subcellular localization of animal proteins with both single and multiple sites. Bioinformatics, 2017, 33(22), 3524-3531.
(b)Cheng, X.; Zhao, S.G.; Xiao, X.; Chou, K.C. Oncotarget, 2017, 8(35), 58494-58503.
(c)Feng, P.; Ding, H.; Yang, H.; Chen, W.; Lin, H.; Chou, K.C. Mol. Ther. Nucleic Acids, 2017, 7(C), 155-163.
(d)Liu, B.; Yang, F.; Chou, K.C. Mol. Ther. Nucleic Acids, 2017, 7(C), 267-277.
(e)Niu, B.; Zhang, M.; Du, P.; Jiang, L.; Qin, R.; Su, Q.; Chen, F.; Du, D.; Shu, Y.; Chou, K-C. Oncotarget, 2017, 8(34), 57149-57162.
(f)Su, Q.; Lu, W.; Du, D.; Chen, F.; Niu, B.; Chou, K-C. Oncotarget, 2017, 8(30), 49359-49369.
(b)Liu, B.; Wu, H.; Chou, K.C. Nat. Sci., 2017, 9(4), 67-91.
(c)Liu, B.; Wu, H.; Zhang, D.; Wang, X.; Chou, K.C. Oncotarget, 2017, 8(8), 13338-13343.
(d)Tahir, M.; Hayat, M.; Kabir, M. Comput. Methods Programs Biomed., 2017, 146, 69-75.
(b)Chou, K.C.; Maggiora, G.M. Protein Eng., 1998, 11(7), 523-538.
(b)Niu, B.; Zhao, M.; Su, Q.; Zhang, M.; Lv, W.; Chen, Q.; Chen, F.; Chu, D.; Du, D.; Zhang, Y. Mol. Divers., 2017, 21(2), 413-426.
(b)Chen, W.; Feng, P.; Ding, H.; Lin, H.; Chou, K-C. Genomics, 2016, 107(2-3), 69-75.
(c)Jia, J.; Liu, Z.; Xiao, X.; Liu, B.; Chou, K.C. J. Theor. Biol., 2015, 377, 47-56.
(d)Liu, B.; Fang, L.; Liu, F.; Wang, X.; Chen, J.; Chou, K.C. PLoS One, 2015, 10(3), e0121501.
(e)Qiu, W.R.; Sun, B.Q.; Xiao, X.; Xu, D.; Chou, K.C. Mol. Inform., 2017, 36(5-6), 1600010.
(f)Xiao, X.; Ye, H.X.; Liu, Z.; Jia, J.H.; Chou, K.C. Oncotarget, 2016, 7(23), 34180-34189.
(b)Cheng, X.; Xiao, X.; Chou, K-C. Mol. Biosyst., 2017, 13(9), 1722-1727.
(c)Cheng, X.; Xiao, X.; Chou, K-C. Gene, 2017, 628, 315-321.
(d)Cheng, X.; Zhao, S-G.; Lin, W-Z.; Xiao, X.; Chou, K-C. Bioinformatics, 2017, 33(22), 3524-3531.
(e)Chou, K-C.; Wu, Z-C.; Xiao, X. Mol. Biosyst., 2012, 8(2), 629-641.