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Review Article

人类病理生理学中干扰素-λ区域和干扰素-λ3内的遗传多态性：他们对结果，治疗和预防肝炎病毒的贡献。

卷 26, 期 25, 2019

页: [4832 - 4851] 页: 20

弟呕挨: 10.2174/0929867325666180719121142

价格: $65

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摘要

干扰素λ（IFN-λ）染色体区域内的遗传多态性（主要是IFN-λ4基因（IFNL4）的rs12979860）被称为与自发性丙型肝炎病毒（HCV）的分解以及对聚乙二醇化干扰素α和 利巴韦林。 IFNL4 rs12979860与IFNL4 rs368234815的强烈连锁不平衡，随即与HCV自发和治疗的根除相关，至少部分解释了rs12979860主要纯合子对HCV有利的结果。 基于IFN的抗病毒治疗的效果与IFN-λ1受体的预处理表达，肝IFN刺激基因的表达，IFN-λ4的产生以及JAK-STAT信号的预激活有关。 如今，直接作用抗病毒药（DAA）已成为治疗丙型肝炎的有效工具，但仍在研究IFN-λs作为潜在的抗病毒药，并且可能是HCV感染的一种选择（DAA耐药性，复发性病毒血症，不良反应）。 免疫能力改变的患者特别容易感染。 在尿毒症患者中，与非尿毒症人群类似，IFN-λ染色体区域内的多态性与自发HCV清除率相关。 循环中的IFN-λ3与针对乙型肝炎病毒（anti-HBs）的表面抗原的抗体的血浆滴度呈正相关，这对于预防乙型肝炎病毒至关重要。 由于IFN-λ3诱导的吲哚胺2，3-二加氧酶（IDO）表达的调节，在更高的IFN-λ3水平下可能会产生更有效的抗HBs。 IFN刺激的应答元件是IDO基因启动子的一部分。 值得进一步研究IDO基因，循环IDO，IFN-λ区域内的遗传多态性和循环IFN-λ3是否在对肝病毒的免疫应答中起协调作用。

关键词: 抗病毒药，乙型肝炎病毒，丙型肝炎病毒，IFNL3，IFNL4，免疫能力，干扰素-λ3，疫苗接种

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