A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

Title:A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

Volume: 15 Issue: 3

Author(s): Valdemar Grill*Bjørn O. Åsvold

Affiliation:

• Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, NO-7491 Trondheim,Norway

Keywords: Autoantibodies, type 1 diabetes, type 2 diabetes, insulin secretion, glutamic acid decarboxylase, GADA.

Abstract: Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

Cite this article as:

Grill Valdemar*, Åsvold O. Bjørn , A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies, Current Diabetes Reviews 2019; 15 (3) . https://dx.doi.org/10.2174/1573399814666180716152342