Abstract
Nitric oxide (NO), produced from L-arginine by the activity of constitutive and inducible NO synthases, has been implicated in a wide range of physiological and pathophysiological processes. Low concentrations of this mediator play homeostatic roles, whereas NO is up-regulated in a number of pathological states and can have damaging effects. Pharmacological modulation of NO levels or NO biosynthesis may be a therapeutic strategy for a number of conditions, although the reported results can be some times controversial. Inhibitors of NO synthases exhibit different selectivity for the neuronal, endothelial or inducible isoforms, which contributes to their beneficial and detrimental effects. Recent developments in this field may offer an alternative for the treatment of inflammatory disorders, pain, neurological diseases, shock, atherosclerosis or cancer.
Keywords: Nitric oxide (NO), carrageenin, iNOS-transduced, Osteoarthritis, Neurotoxicity, monomethyl-L-arginine (L-NMMA), Tetrahydrobiopterin analogues, Mercaptoethylguanidine, Cyclo-oxygenase, Leukotriene, N-methyl-D-aspartate
Current Pharmaceutical Design
Title: Nitric Oxide Related Therapeutic Phenomenon: A Challenging Task
Volume: 8 Issue: 3
Author(s): M. J. Alcaraz and M. I. Guillen
Affiliation:
Keywords: Nitric oxide (NO), carrageenin, iNOS-transduced, Osteoarthritis, Neurotoxicity, monomethyl-L-arginine (L-NMMA), Tetrahydrobiopterin analogues, Mercaptoethylguanidine, Cyclo-oxygenase, Leukotriene, N-methyl-D-aspartate
Abstract: Nitric oxide (NO), produced from L-arginine by the activity of constitutive and inducible NO synthases, has been implicated in a wide range of physiological and pathophysiological processes. Low concentrations of this mediator play homeostatic roles, whereas NO is up-regulated in a number of pathological states and can have damaging effects. Pharmacological modulation of NO levels or NO biosynthesis may be a therapeutic strategy for a number of conditions, although the reported results can be some times controversial. Inhibitors of NO synthases exhibit different selectivity for the neuronal, endothelial or inducible isoforms, which contributes to their beneficial and detrimental effects. Recent developments in this field may offer an alternative for the treatment of inflammatory disorders, pain, neurological diseases, shock, atherosclerosis or cancer.
Export Options
About this article
Cite this article as:
Alcaraz J. M. and Guillen I. M., Nitric Oxide Related Therapeutic Phenomenon: A Challenging Task, Current Pharmaceutical Design 2002; 8 (3) . https://dx.doi.org/10.2174/1381612023396447
DOI https://dx.doi.org/10.2174/1381612023396447 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pleiotropic Effects of Rimonabant: Clinical Implications
Current Pharmaceutical Design Humoral and Cellular Immunity Against Cryptosporidium Infection
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents
Mini-Reviews in Medicinal Chemistry Integrated Biomarkers for Depression in Alzheimer’s Disease: A Critical Review
Current Alzheimer Research The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study
Current Nutrition & Food Science Antisense Oligonucleotides for the Treatment of Dyslipidemia
Current Pharmaceutical Design Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV Positive Patient with Secondary Syphilis
Recent Patents on Inflammation & Allergy Drug Discovery Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection?
Current Organic Chemistry The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans
Current Drug Metabolism 3D-QSAR and Docking Studies on Pyrrolopyrimidine Derivatives as LIM-Kinase 2 Inhibitors
Letters in Drug Design & Discovery Identification of Tumor Targeting Agents by Phage Display
Medicinal Chemistry Reviews - Online (Discontinued) Development and Anti-microbial Potential of Topical Formulations Containing Cocos nucifera Linn.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Proteomic Studies Using Microarrays
Current Proteomics Discovery and ADMET: Where Are We Now
Current Topics in Medicinal Chemistry Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates
Current Medicinal Chemistry Structural Biology of the Cell Adhesion Protein CD2: From Molecular Recognition to Protein Folding and Design
Current Protein & Peptide Science Phytosterols in Physiological Concentrations Target Multidrug Resistant Cancer Cells
Medicinal Chemistry Production of Retroviral Vectors: Review
Current Gene Therapy Vaccines for Cytomegalovirus
Infectious Disorders - Drug Targets Dendritic Cells in Autoimmune Liver Diseases
Current Immunology Reviews (Discontinued)