Abstract
A continuous-flow procedure was hereby developed and introduced for the synthesis of etherified tryptophol derivatives. It evolved Fischer indolization and condensation in tandem by using Lewis acid as a catalyst. Solvent (alcohol) was considered to participate in the reaction sequence during the step of etherification which is not readily available through traditional approaches. The reaction time of heating and cooling was precisely controlled in flow that would benefit the scale-up (short residence time) and increasing yield (high selectivity).
Keywords: Etherified tryptophol derivatives, flow chemistry, Fischer indolization, etherification, single-stage flow, 7-ethyl tryptophol, Lewis acid.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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