[1]
Veeresham C. Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res 2012; 3: 200-20.
[2]
Hobbs C. Valerian and other anti-hysterics in European and American medicine. Pharm Hist 1990; 32(3): 132-7.
[3]
WHO. Monographs on selected medicinal plants v1. Malta: WHO Graphics 1999.
[4]
Hattesohl M, Feistel B, Sievers H, Lehnfeld R, Hegger M, Winterhoff H. Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine 2008; 15(1-2): 2-15.
[5]
Subhan F, Karim N, Gilani AH, Sewell RDE. Terpenoid content of Valeriana wallichii extracts and antidepressant-like response profiles. Phytother Res 2010; 24(5): 686-91.
[6]
Holzmann I, Filho VC, Mora TC, et al. Evaluation of behavioral and pharmacological effects of hydroalcoholic extract of Valeriana prionophylla Standl, 2011. J Evid Based Complementary Altern Med 2011. Article ID 312320
[7]
Sah SP, Mathela CS, Chopra K. Antidepressant effect of Valeriana wallichii patchouli alcohol chemotype in mice: Behavioural and biochemical evidence. J Ethnopharmacol 2011; 135(1): 197-200.
[8]
Müller LG, Salles LA, Stein AC, et al. Antidepressantlike effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice. Prog Neuropsychopharmacol Biol Psychiatry 2012a; 36(1): 101-9.
[9]
Subhan F, Karim N, Ibrar M. Anti-inflammatory activity of methanolic and aqueos extracts of Valeriana wallichii DC rhizome. Pak J Plant Sci 2007; 13: 103-8.
[10]
Zhang Z-L, Zuo Y-M, Wang Q-H, Xiao H-B, Kuang H-X. Effects of Valeriana amurensis on the expressions of iNOS, COX-2 and IkappaCB-alpha in Alzheimer’s disease model rat’s brain. Zhong Yao Cai 2010; 33(4): 581-3.
[11]
Khuda F, Iqbal Z, Khan A, Nasir F, Shah Y. Antiinflammatory activity of the topical preparation of Valeriana wallichii and Achyranthes aspera leaves. Pak J Pharm Sci 2013; 26(3): 451-4.
[12]
Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC. 6- Methylapigenin and hesperidin: New Valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav 2003; 75: 537-45.
[13]
Benke D, Barberis A, Kopp S, et al. GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 2009; 56: 174-81.
[14]
Andreatini R, Sartori VA, Seabra MLV, Leite JR. Effect of valepotriates (valerian extract) in generalized anxiety disorder: A randomized placebo-controlled pilot study. Phytother Res 2002; 16(7): 650-4.
[15]
Maurmann N, Reolon GK, Rech SB, Fett-Neto AG, Roesler R. A valepotriate fraction of Valeriana glechomifolia shows sedative and anxiolytic properties and impairs recognition but not aversive memory in mice. J Evid Based Complementary Altern Med 2011; Article ID 720853.
[16]
Müller LG, de Andrade Salles L, Sakamoto S, et al. Effect of storage time and conditions on the diene valepotriates content of the extract of Valeriana glechomifolia obtained by supercritical carbon dioxide. Phytochem Anal 2012b; 23(3): 222-7.
[17]
Müller LG, Salles L, Lins HA, et al. Effects of diene valepotriates from Valeriana glechomifolia on Na+/K+-ATPase activity in the cortex and hippocampus of mice. Planta Med 2015a; 81: 200-7.
[18]
Müller LG, Borsoi M, Stolz ED, et al. Diene valepotriates from Valeriana glechomifolia prevent lipopolysaccharide-induced sickness and depressive-like behavior in mice. J Evid Based Complementary Altern Med 2015b. Article ID 145914
[19]
Müller LG, Stolz ED, Betti AH, Herzfeldt V, Rates SM. Synergistic interaction between diene valepotriates from Valeriana glechomifolia meyer. J Pharm Pharmacol 2015c; 67: 1008-16.
[20]
Silva AL, Rech SB, von Poser GL. Quantitative determination of valepotriates from Valeriana native to South Brazil. Planta Med 2002; 68(6): 570-2.
[21]
Al-Majed AA, Al-Yahya AA, Al-Bekairi AM, Al-Shabanah OA, Qureshi S. Studies on the cytological and biochemical effects of valerian in somatic and germ cells of Swiss albino mice. Food Chem Toxicol 2006; 44: 1830-7.
[22]
Bounthanh C, Bergmann C, Beck JP, Haag-Berruier M, Anton R. Valepotriates, a new class of citotoxic and antitumor agents. Planta Med 1981; 41: 21-8.
[23]
Bounthanh C, Richert L, Beck JP, Haag-Berrurier M, Anton R. The action of valepotriates on the synthesis of DNA and proteins of cultured hepatoma cells. Planta Med 1983; 49: 138-42.
[24]
Hui-Lian W, Dong-Fang Z, Zhao-Feng L, Yang L, Qian-Rong W, Yu-Zhen W. In vitro study on the genotoxicity of dichloromethane extracts of valerian (DEV) in human endothelial ECV304 cells and the effect of vitamins E and C in attenuating the DEV-induced DNA damages. Toxicol Appl Pharmacol 2003; 188: 26-41.
[25]
Lin S, Shen YH, Li HL, et al. Acylated iridoids with cytotoxicity from Valeriana jatamansi. J Nat Prod 2009; 72: 650-5.
[26]
Tufik S, Fujita K. de L Seabra M, Lobo LL. Effects of a prolonged administration of valepotriates in rats on the mothers and their offspring. J Ethnopharmacol 1994; 41: 39-44.
[27]
Cassel E, Vargas RMF, Brun GW, et al. Supercritical fluid extraction of alkaloids from Ilex paraguariensis St. Hil. J Food Eng 2010; 100(4): 656-61.
[28]
Ministério da Ciência, Tecnologia e Inovação, CONCEA, Diretriz brasileira para o cuidado e a utilização de animais para fins científicos e didáticos—DBCA, Portaria no. 465, de 23 de maio de 2013, Brasilia, Brasil, 2013.
[29]
Ministério da Ciência, Tecnologia e Inovação, CONCEA, diretrizes da prática de eutanásia do CONCEA, Portaria no. 596, de 25 de junho de 2013, Brasília, Brasil, 2013.
[30]
Ministério Público, Brasília, Brasil, Lei no. 11.794, de 8 de outubro de 2008, Publicada no DOU 9.10.2008
[31]
OECD. Guideline 407. Repeated-dose 28-day Oral Toxicity Study in Rodents. Adopted by the Council on 27th July, 1995.
[32]
OECD. Guideline 423. Acute Oral Toxicity - Acute Toxic Class Method. Adopted by the Council on 17th December, 2001.
[33]
Betti AH, Stein AC, Dallegrave E, et al. Acute and repeated-doses (28 days) toxicity study of Hypericum polyanthemum Klotzsch ex Reichardt (Guttiferare) in mice. Food Chem Toxicol 2012; 50: 2349-55.
[34]
De Meijer VE, Le HD, Meisel JA, Puder M. Repetitive orogastric gavage affects the phenotype of diet-induced obese mice. Physiol Behav 2010; 100(4): 387-93.
[35]
Braun R, Dittmar W, Machut M, Weickmann S. Valepotriates with epoxide structure as alkylating agents. Dtsch Apoth Ztg 1982; 122: 1109-13.
[36]
Yao M, Ritchie HE, Brown-Woodman PD. A developmental toxicity-screening test of valerian. J Ethnopharmacol 2007; 113: 204-9.
[37]
Bos R, Hendriks H, Scheffer C, Waerdenbag H. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine 1998; 5(3): 219-25.
[38]
Tortarolo M. In vitro effects of epoxide-bearing valepotriates on mouse early hematopoietic progenitor cells and human T-lymphocytes. Arch Toxicol 1982; 51: 37-42.
[39]
Hobbs C. Valerian: A literature review. Herbalgram 1989; 21: 19-34.
[40]
Huang Q, Riviere JE. The application of allometric scaling principles to predict pharmacokinetic parameters across species. Expert Opin Drug Metab Toxicol 2014; 10(9): 1241-53.
[41]
Antonio CB, Dalla Costa T, Neves GA, Rates SMK. Doses obtidas em farmacologia pré-clínica para ensaios clínicos fase 1: Antipsicóticos como estudo de caso. Lat Am J Pharm 2009; 28(5): 715-22.
[42]
Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, Sancho-Gómez P, Calbó-Caldentey C, Flores-Mateo G. Effectiveness of Valerian on insomnia: A meta-analysis of randomized placebo-controlled trials. Sleep Med 2010; 11(6): 505-11.
28
3