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Review Article

天然膳食剂对多发性骨髓瘤预防和治疗的影响:分子研究和临床转化的潜力

卷 27, 期 2, 2020

页: [187 - 215] 页: 29

弟呕挨: 10.2174/0929867325666180629153141

价格: $65

摘要

化学预防是基于使用无毒、有药理活性的药物，来防止肿瘤恶化。在这方面，最近的文献认为天然膳食剂是控制恶性肿瘤发病和恶化的有前景的工具。迄今为止，人们进行了广泛的研究，以阐明天然产物对肿瘤生长和生存的影响，揭示了此类化合物所针对的最相关的信号转导途径。总之，流行病学或动物研究的结果甚至临床试验都支持膳食剂对肿瘤细胞抗炎，抗氧化和细胞毒性的作用。多发性骨髓瘤是一种血液系统恶性肿瘤，其特征是骨髓浆细胞异常增生，并伴有高钙血症、肾功能不全、贫血或骨病，尽管有新的治疗方法，但仍无法治愈。值得注意的是，越来越多的证据支持饮食天然化合物在该病的临床前模型中对抗多发性骨髓瘤生长的能力，并强调其作为候选抗癌药物的潜力。在这篇综述中，我们旨在总结膳食天然产物的抗肿瘤活性的研究结果，重点介绍其分子机制，包括抑制致癌信号转导途径和/或表观遗传调节作用，以及它们对抗多发性骨髓瘤及其相关骨病的潜在临床应用。

关键词: 癌症化学预防，天然抗癌治疗，多发性骨髓瘤，食疗剂，天然化合物。

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