Login Register Cart 0
Generic placeholder image

Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Albendazole and Treatment of Hydatid Cyst: Review of the Literature

Author(s): Azar B. Dehkordi, Behnam Sanei, Morteza Yousefi, Seyedeh M. Sharafi, Farhang Safarnezhad, Rasool Jafari and Hossein Y. Darani*

Volume 19, Issue 2, 2019

Page: [101 - 104] Pages: 4

DOI: 10.2174/1871526518666180629134511

Price: $65

Abstract

Human hydatid cyst or cystic echinococcosis is a life-threatening zoonotic disease that occurs in most countries worldwide and is recognized as a major public health problem. Following ingestion of Echinococcus granulosus eggs, hydatid cysts which are the larval stage of the worm are formed mostly in liver and lungs, and occasionally in other organs of human.The usual treatment for hydatid cyst is open surgery. One of the problems following surgery is the recurrence. In the last decades, albendazole has been used for the treatment of hydatid cyst. This drug can be used alone or jointly with surgical procedures. However, its efficacy has not been well documented. Thus, in this work, the treatment of hydatid cyst with albendazole in different investigations including case studies, clinical trials in human and experimental works in animals has been reviewed. According to the findings of this review, it can be concluded that treatment of hydatid cyst with albendazole may be associated with the prevention of recurrence and reduction of the size and death of the hydatid cysts.

Keywords: Hydatid cyst, albendazole, treatment, cystic echinococcosis, size, death.

Graphical Abstract

[1]
Jenkins, D.J.; Romig, T.; Thompson, R.C. Emergence/re-emergence of Echinococcus spp.--a global update. Int. J. Parasitol., 2005, 35(11-12), 1205-1219.
[2]
Budke, C.M.; Deplazes, P.; Torgerson, P.R. Global socioeconomic impact of cystic echinococcosis. Emerg. Infect. Dis., 2006, 12(2), 296-303.
[3]
Seimenis, A. Overview of the epidemiological situation on echinococcosis in the Mediterranean region. Acta Trop., 2003, 85(2), 191-195.
[4]
Sotiraki, S.; Himonas, C.; Korkoliakou, P. Hydatidosis-echino-coccosis in Greece. Acta Trop., 2003, 85(2), 197-201.
[5]
Lorenzini, R.; Ruggieri, A. Distribution of echinococcosis/hydati-dosis in Italy. J. Helminthol., 1987, 61(3), 261-267.
[6]
Rojo-Vazquez, F.A.; Pardo-Lledias, J.; Francos-Von Hunefeld, M.; Cordero-Sanchez, M.; Alamo-Sanz, R.; Hernandez-Gonzalez, A.; Brunetti, E.; Siles-Lucas, M. Cystic echinococcosis in Spain: current situation and relevance for other endemic areas in Europe. PLoS Negl. Trop. Dis., 2011, 5(1)e893
[7]
Mandal, S.; Mandal, M.D. Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects. Asian Pac. J. Trop. Med., 2012, 5(4), 253-260.
[8]
Craig, P.S.; McManus, D.P.; Lightowlers, M.W.; Chabalgoity, J.A.; Garcia, H.H.; Gavidia, C.M.; Gilman, R.H.; Gonzalez, A.E.; Lorca, M.; Naquira, C.; Nieto, A.; Schantz, P.M. Prevention and control of cystic echinococcosis. Lancet Infect. Dis., 2007, 7(6), 385-394.
[9]
Moro, P.L.; Schantz, P.M. Echinococcosis: historical landmarks and progress in research and control. Ann. Trop. Med. Parasitol., 2006, 100(8), 703-714.
[10]
McManus, D.P.; Zhang, W.; Li, J.; Bartley, P.B. Echinococcosis. Lancet, 2003, 362(9392), 1295-1304.
[11]
Gollackner, B.; Längle, F.; Auer, H.; Maier, A.; Mittlböck, M.; Agstner, I.; Karner, J.; Langer, F.; Aspöck, H.; Loidolt, H.; Rockenschaub, S.; Steininger, R. Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J. Surg., 2000, 24(6), 717-721.
[12]
Bennett, JE; Dolin, R; Blaser, MJ Douglas, and Bennett's Principles and Practice of In-fectious Diseases E-Book: Elsevier Health Sciences. 2014.
[13]
Rampal, K.; Prajapati, D.K.; Sharma, M. Hydatid Disease-A Clinical Perspective with A Review of Primary Hydatidosis of Spleen. Int J Intg Med Sci., 2016, 3(7), 337-340.
[14]
Grosso, G.; Gruttadauria, S.; Biondi, A.; Marventano, S.; Mistretta, A. Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J. Gastroenterol., 2012, 18(13), 1425-1437.
[15]
Alonso Casado, O.; Moreno González, E.; Loinaz Segurola, C.; Gimeno Calvo, A.; González Pinto, I.; Pérez Saborido, B.; Paseiro Crespo, G.; Ortiz Johansson, C. Results of 22 years of experience in radical surgical treatment of hepatic hydatid cysts. Hepatogastroenterology, 2001, 48(37), 235-243.
[16]
Vuitton, D.; Meslin, F.; MacPherson, C.; Brunetti, E.; Filice, C. World Health Organization Informal Working Group on echinococcosis. PAIR: an option for the treatment of cystic echinococcosis. Bull. World Health Organ., 2002.
[17]
Menezes da Silva, A. Hydatid cyst of the liver-criteria for the selection of appropriate treatment. Acta Trop., 2003, 85(2), 237-242.
[18]
Morris, D.L. Pre-operative albendazole therapy for hydatid cyst. Br. J. Surg., 1987, 74(9), 805-806.
[19]
Stamatakos, M.; Sargedi, C.; Stefanaki, Ch.; Safioleas, C.; Matthaiopoulou, I.; Safioleas, M. Anthelminthic treatment: an adjuvant therapeutic strategy against Echinococcus granulosus. Parasitol. Int., 2009, 58(2), 115-120.
[20]
Shams-Ul-Bari, SHA; Malik, AA; Khaja, AR; Dass, TA; Naikoo, ZA Role of albendazole in the management of hydatid cyst liver. Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association, 2011, 17(5), 343.
[21]
Smego, R.A., Jr; Sebanego, P. Treatment options for hepatic cystic echinococcosis. Int. J. Infect. Dis., 2005, 9(2), 69-76.
[22]
Saimot, A.G.; Adrien, G. Medical treatment of liver hydatidosis. World J. Surg., 2001, 25(1), 15-20.
[23]
Kern, P. Echinococcus granulosus infection: clinical presentation, medical treatment and outcome. Langenbecks Arch. Surg., 2003, 388(6), 413-420.
[24]
Falagas, M.E.; Bliziotis, I.A. Albendazole for the treatment of human echinococcosis: a review of comparative clinical trials. Am. J. Med. Sci., 2007, 334(3), 171-179.
[25]
Teggi, A.; Capozzi, A.; De Rosa, F. Treatment of Echinococcus granulosus hydatid disease with mebendazole. J. Chemother., 1989, 1(5), 310-317.
[26]
Teggi, A.; Lastilla, M.G.; De Rosa, F. Therapy of human hydatid disease with mebendazole and albendazole. Antimicrob. Agents Chemother., 1993, 37(8), 1679-1684.
[27]
Bartoloni, C.; Tricerri, A.; Guidi, L.; Gambassi, G. The efficacy of chemotherapy with mebendazole in human cystic echinococcosis: long-term follow-up of 52 patients. Ann. Trop. Med. Parasitol., 1992, 86(3), 249-256.
[28]
Rippmann, K; Dietrich, M; Kern, P Long-term therapy of cystic liver echinococcosis with mebendazole. Medizinische Klinik (Munich, Germany: 1983), 1992, 87(7), 350-4.
[29]
Morris, D.L.; Dykes, P.W.; Marriner, S.; Bogan, J.; Burrows, F.; Skeene-Smith, H.; Clarkson, M.J. Albendazole--objective evidence of response in human hydatid disease. JAMA, 1985, 253(14), 2053-2057.
[30]
Saimot, A.G.; Meulemans, A.; Cremieux, A.C.; Giovanangeli, M.D.; Hay, J.M.; Delaitre, B.; Coulaud, J.P. Albendazole as a potential treatment for human hydatidosis. Lancet, 1983, 2(8351), 652-656.
[31]
Chu, S.W.; Badar, S.; Morris, D.L.; Pourgholami, M.H. Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole. Anticancer Res., 2009, 29(10), 3791-3796.
[32]
Lacey, E. Mode of action of benzimidazoles. Parasitol. Today (Regul. Ed.), , 1990; 6, pp. (4)112-115.
[33]
Lacey, E. The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles. Int. J. Parasitol., 1988, 18(7), 885-936.
[34]
Friedman, P.A.; Platzer, E.G. Interaction of anthelmintic benzimidazoles with AscarisSuum embryonic tubulin. Biochimica et Biophysica Acta (BBA)-. General Subjects., 1980, 630(2), 271-278.
[35]
El-On, J. Benzimidazole treatment of cystic echinococcosis. Acta Trop., 2003, 85(2), 243-252.
[36]
Kuyumcu, M.E.; Yeşil, Y.; Etgül, S.; Halaçli, B.; Sunman, H.; Yavuz, B.B.; Hazirolan, T.; Halil, M.; Cankurtaran, M.; Ariogul, S. Inoperable isolated cardiac hydatid cyst controlled with albendazole in an older adult with dementia. Age Ageing, 2013, 42(6), 812-814.
[37]
Baykaner, M.K.; Doğulu, F.; Oztürk, G.; Edali, N.; Tali, T. A viable residual spinal hydatid cyst cured with albendazole. Case report. J. Neurosurg., 2000, 93(1)(Suppl.), 142-144.
[38]
Eser, İ; Şeker, A; Günay, Ş; Aydın, MS; Sak, ZHA; Yalçın, F Çoklu organ tutulumlu hidatik kist hastasında al-bendazol tedavisinin etkinliği. Dicle Tıp Dergisi, 2013, 40(4)
[39]
Awasthy, N.; Chand, K. Primary hydatid disease of the spine: an unusual case. Br. J. Neurosurg., 2005, 19(5), 425-427.
[40]
García-Vicuña, R.; Carvajal, I.; Ortiz-García, A.; López-Robledillo, J.C.; Laffón, A.; Sabando, P. Primary solitary Echinococcosis in cervical spine. Postsurgical successful outcome after long-term albendazole treatment. Spine, 2000, 25(4), 520-523.
[41]
Dellamonica, P.; Le Fichoux, Y. [Spinal hydatidosis. Failure of albendazole]. [Spinal hydatidosis. Failure of albendazole]. Pathol. Biol. (Paris), 1986, 34(4), 295-296.
[42]
Özdemir, H.M.; Ogün, T.C.; Tasbas, B. A lasting solution is hard to achieve in primary hydatid disease of the spine: long-term results and an overview. Spine, 2004, 29(8), 932-937.
[43]
Mahouachi, R.; Berraies, A.; Taktak, S.; Chtourou, A.; Kheder, A.B. Pulmonary hydatid cyst embolization successfully treated with albendazole. Respiratory Medicine Extra., 2007, 3(4), 192-194.
[44]
Jimenénez-Mejías, M.E.; Alarcón-Cruz, J.C.; Márquez-Rivas, F.J.; Palomino-Nicás, J.; Montero, J.M.; Pachón, J. Orbital hydatid cyst: treatment and prevention of recurrences with albendazole plus praziquantel. J. Infect., 2000, 41(1), 105-107.
[45]
Erzurumlu, K.; Özdemir, M.; Mihmanli, M.; Cevikbaş, U. The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. Eur. Surg. Res., 1995, 27(5), 340-345.
[46]
Gil-Grande, L.A.; Rodriguez-Caabeiro, F.; Prieto, J.G.; Sánchez-Ruano, J.J.; Brasa, C.; Aguilar, L.; García-Hoz, F.; Casado, N.; Bárcena, R.; Alvarez, A.I.; Dal-Ré, R. Randomised controlled trial of efficacy of albendazole in intra-abdominal hydatid disease. Lancet, 1993, 342(8882), 1269-1272.
[47]
Okelo, G.B. III Hydatid disease: research and control in Turkana, III. Albendazole in the treatment of inoperable hydatid disease in Kenya--a report on 12 cases. Trans. R. Soc. Trop. Med. Hyg., 1986, 80(2), 193-195.
[48]
Davis, A.; Dixon, H.; Pawlowski, Z.S. Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). Bull. World Health Organ., 1989, 67(5), 503-508.
[49]
Keshmiri, M.; Baharvahdat, H.; Fattahi, S.H.; Davachi, B.; Dabiri, R.H.; Baradaran, H.; Rajabzadeh, F. Albendazole versus placebo in treatment of echinococcosis. Trans. R. Soc. Trop. Med. Hyg., 2001, 95(2), 190-194.
[50]
Arif, S.H. Shams-Ul-Bari; Wani, N.A.; Zargar, S.A.; Wani, M.A.; Tabassum, R.; Hussain, Z.; Baba, A.A.; Lone, R.A. Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int. J. Surg., 2008, 6(6), 448-451.
[51]
Mohammadi, A.; Sabet, B.; Amini, M.; Mohammadi, M. Short-Course Combination therapy with Albendazole and Praziquantel Chemotherapy in recurrent complicated case of vertebral hydatidosis. Iran. Red Crescent Med. J., 2008, 2008(3), 241-243.
[52]
Lam, K.S.; Faraj, A.; Mulholland, R.C.; Finch, R.G. Medical decompression of vertebral hydatidosis. Spine, 1997, 22(17), 2050-2055.
[53]
Alvela-Suárez, L.; Velasco-Tirado, V.; Belhassen-Garcia, M.; Novo-Veleiro, I.; Pardo-Lledías, J.; Romero-Alegría, A.; Pérez del Villar, L.; Valverde-Merino, M.P.; Cordero-Sánchez, M. Safety of the combined use of praziquantel and albendazole in the treatment of human hydatid disease. Am. J. Trop. Med. Hyg., 2014, 90(5), 819-822.
[54]
Cobo, F.; Yarnoz, C.; Sesma, B.; Fraile, P.; Aizcorbe, M.; Trujillo, R.; Diaz-de-Liaño, A.; Ciga, M.A. Albendazole plus praziquantel versus albendazole alone as a pre-operative treatment in intra-abdominal hydatisosis caused by Echinococcus granulosus. Trop. Med. Int. Health, 1998, 3(6), 462-466.
[55]
Razmi, G.; Hashemi Tabar, G.; Maleki, M. In vivo effect of albendazole and mebendazole on hydatid cyst of mice. Arch. Razi Inst., 2016, 64(1), 45-50.
[56]
Riganò, R.; Profumo, E.; Ioppolo, S.; Notargiacomo, S.; Ortona, E.; Teggi, A.; Siracusano, A. Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease. Clin. Exp. Immunol., 1995, 102(2), 281-285.
[57]
Riganò, R.; Profumo, E.; Buttari, B.; Teggi, A.; Siracusano, A. Cytokine gene expression in peripheral blood mononuclear cells (PBMC) from patients with pharmacologically treated cystic echinococcosis. Clin. Exp. Immunol., 1999, 118(1), 95-101.
[58]
Riganò, R.; Profumo, E.; Bruschi, F.; Carulli, G.; Azzarà, A.; Ioppolo, S.; Buttari, B.; Ortona, E.; Margutti, P.; Teggi, A.; Siracusano, A. Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. Infect. Immun., 2001, 69(1), 288-296.
[59]
Riganò, R.; Profumo, E.; Ioppolo, S.; Notargiacomo, S.; Teggi, A.; Siracusano, A. Serum cytokine detection in the clinical follow up of patients with cystic echinococcosis. Clin. Exp. Immunol., 1999, 115(3), 503-507.
[60]
Riganò, R.; Profumo, E.; Di Felice, G.; Ortona, E.; Teggi, A.; Siracusano, A. In vitro production of cytokines by peripheral blood mononuclear cells from hydatid patients. Clin. Exp. Immunol., 1995, 99(3), 433-439.
[61]
Dvoroznáková, E.; Hrcková, G.; Borosková, Z.; Velebný, S.; Dubinský, P. Effect of treatment with free and liposomized albendazole on selected immunological parameters and cyst growth in mice infected with Echinococcus multilocularis. Parasitol. Int., 2004, 53(4), 315-325.
[62]
Papathanassiou, M.; Petrou, P.; Zampeli, E.; Vergados, I.; Paikos, P. Disseminated hydatid disease in a child: albendazole treatment of orbital cyst. Eur. J. Ophthalmol., 2008, 18(6), 1034-1036.

Rights & Permissions Print Cite
Article Metrics
93
6
1
1
© 2024 Bentham Science Publishers | Privacy Policy