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Review Article

偏头痛的能量代谢障碍

卷 26, 期 34, 2019

页: [6253 - 6260] 页: 8

弟呕挨: 10.2174/0929867325666180622154411

价格: $65

摘要

偏头痛是一种常见的致残性神经系统疾病，其特征是与各种感觉和自主神经症状相关的复发性头痛。尽管涉及中枢神经系统和周围神经系统的许多机制现在已经很清楚，但偏头痛的病理生理学仍未完全了解。特别是，偏头痛与大脑的能量代谢障碍有关，这已被广泛接受。这篇综述的目的是介绍偏头痛病理生理中能量代谢的最新概况。几项生化，形态学和磁共振波谱研究已经证实，偏头痛患者存在能量生产不足以及能量消耗增加的现象。超过一定阈值的能量需求增加为偏头痛发作的发生创造了代谢和生化前提。偏头痛中氧化能代谢的缺陷是普遍存在的。偏头痛的线粒体缺陷是原发性还是继发性尚待确定。生理上与线粒体呼吸链功能有关的核黄素和辅酶Q10在预防偏头痛方面有效，支持了改善脑能量代谢可降低偏头痛敏感性的假设。

关键词: 能量代谢，线粒体功能障碍，偏头痛，氧化磷酸化，磁共振波谱，生物能学缺陷。

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