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Review Article

偏头痛中的循环生物标志物：精准医学的新机会

卷 26, 期 34, 2019

页: [6191 - 6206] 页: 16

弟呕挨: 10.2174/0929867325666180622122938

价格: $65

摘要

背景：偏头痛是最常见的神经系统疾病，也是人类第二大致残的疾病，遗传，表观遗传和环境因素共同促进了偏头痛的发病。近年来，已经做出了一些努力来鉴定可靠的生物标志物，所述生物标志物可用于监测疾病活动和/或确定对特定治疗的反应。 目的：综述有关偏头痛的潜在生物学标志物的最新证据。 方法：通过检索截至2017年12月的主要出版物数据库，对经过同行评审的研究文献进行结构化搜索。 结果：已经提出了几种循环生物标记物作为偏头痛的诊断或治疗工具，主要与偏头痛的炎症病理生理学方面有关。尽管如此，对它们的检测仍然是科学界的一个挑战，至少部分反映了疾病的复杂性和临床诊断的局限性。目前，降钙素基因相关肽（CGRP）可能代表最有前途的候选物作为诊断和/或治疗生物标志物，因为其偏头痛发作期间血浆水平升高而成功治疗期间降低。尽管有希望，其他分子（包括一些神经肽，细胞因子，脂肪因子或血管激活标记物）却没有足够的先决条件被视为偏头痛生物标记物。 结论：偏头痛特异性生物标志物的表征从精密医学的角度来看至关重要，可以进行风险评估和量身定制的治疗方法。然而，推测偏头痛生物标志物的临床有效性可能为时过早，目前需要进行对照的临床试验来研究这些生物标志物在偏头痛中的诊断和治疗价值。

关键词: 偏头痛，头痛，炎症，生物标志物，降钙素基因相关肽，细胞因子，高敏C反应蛋白。

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