Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Title:Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Volume: 18 Issue: 10

Author(s): Salma E. Ahmed, Nahid Awad, Vinod Paul, Hesham G. Moussa and Ghaleb A. Husseini*

Affiliation:

• Department of Chemical Engineering, American University of Sharjah, Sharjah,United Arab Emirates

Keywords: Chemotherapy, multi-drug resistance, anthracyclines, doxorubicin, nano-carriers, ultrasound.

Abstract: Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Cite this article as:

Ahmed E. Salma , Awad Nahid, Paul Vinod , Moussa G. Hesham and Husseini A. Ghaleb *, Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release, Current Topics in Medicinal Chemistry 2018; 18 (10) . https://dx.doi.org/10.2174/1568026618666180608125344