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Review Article

乳蛋白阳离子脂质的载脂效果综述：脂质传递的潜在应用

卷 27, 期 24, 2020

页: [4109 - 4117] 页: 9

弟呕挨: 10.2174/0929867325666180608122439

价格: $65

摘要

在这篇综述中，辅助剂和阳离子脂质胆固醇（CHOL），1,2-二油酰基-3-三甲基铵丙烷（DOTAP），二十八烷基二甲基溴化铵（DDAB）和二油酰基磷脂酰乙醇胺（DOPE）的装载效率在生理条件下在水溶液中比较了乳球蛋白，α-酪蛋白和β-酪蛋白。 结构分析表明，脂质通过与DOTAP和DDAB的亲水，疏水和H键接触而结合牛奶蛋白，形成更稳定的蛋白结合物。 负载效率为30-50％，并通过阳离子脂质增强。 脂质结合改变了蛋白质构象，导致部分蛋白质结构不稳定。 牛奶蛋白能够在体外转运脂质。

关键词: 牛奶蛋白，脂质，负荷效能，光谱学，模型，阳离子脂质胆固醇。

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