Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach

Title:Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach

Volume: 5 Issue: 2

Author(s): Satya Karuna Pulakhandam, Annem Siva Reddy, Naresh Kumar Katari*, Ravi Prakash Reddy Manda and Sreekantha B. Jonnalagadda*

Affiliation:

• Department of Chemistry, GITAM School of Technology, GITAM University, HTP campus, Rudraram, Medak, Telangana 502 329,India

• School of Chemistry & Physics, University of KwaZulu-Natal, P Bag X 54001, Durban 4000,south africa

Keywords: Oxone, sulfones, thioquinazolines, chemo-selective, optimization, m-CPBA.

Abstract: Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted thio quinazoline compounds as substrates. All the twelve products were characterized by melting range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.

Cite this article as:

Pulakhandam Karuna Satya , Reddy Siva Annem, Katari Kumar Naresh *, Manda Prakash Reddy Ravi and Jonnalagadda B. Sreekantha*, Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach, Current Green Chemistry 2018; 5 (2) . https://dx.doi.org/10.2174/2213346105666180605123417