Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines

Title:Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines

Volume: 18 Issue: 12

Author(s): Raquel P. Souza*, Patrícia S. Bonfim-Mendonça, Gabrielle M.Z.F. Damke, Analine R.B. de-Assis Carvalho, Bianca A. Ratti, Djaceli S. O. Dembogurski, Vânia R.S. da-Silva, Sueli O. Silva, Denise B. Da-Silva, Marcos L. Bruschi, Silvya S. Maria-Engler and Marcia E.L. Consolaro

Affiliation:

• Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana,Brazil

Keywords: Artepillin C, propolis, cervical cancer, apoptosis, cell migration and invasion, oxidative stress.

Abstract: Background: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer.

Method: To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT).

Results: Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer-derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells.

Conclusion: Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types.

Cite this article as:

Souza P. Raquel *, Bonfim-Mendonça S. Patrícia , Damke M.Z.F. Gabrielle , de-Assis Carvalho R.B. Analine, Ratti A. Bianca , Dembogurski S. O. Djaceli , da-Silva R.S. Vânia, Silva O. Sueli , Da-Silva B. Denise , Bruschi L. Marcos , Maria-Engler S. Silvya and Consolaro E.L. Marcia , Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (12) . https://dx.doi.org/10.2174/1871520618666180604092930