摘要
心血管并发症是2型糖尿病患者发病率和死亡率高的主要原因之一,使得心血管并发症的治疗成为治疗2型糖尿病的重要组成部分。 同样,美国食品和药物管理局要求所有新的糖尿病药物和疗法都具有安全的心血管特征。 在可用于治疗2型糖尿病的各种药物中,钠 - 葡萄糖协同转运蛋白2(SGLT2)抑制剂代表一类新开发的抗糖尿病药,其具有降低2型糖尿病患者心血管风险的性质。 来自临床试验的证据表明,SGLT2抑制剂依帕列净和canagliflozin能够降低2型糖尿病患者心血管事件和死亡的总体风险。 在这篇小型综述中,我们将简要讨论SGLT2抑制剂的各种心血管益处,以及所涉及的潜在机制
关键词: SGLT2,GLP-1,DPP-4,2型糖尿病,心血管,临床。
图形摘要
Current Drug Targets
Title:Cardiovascular Benefit of SGLT2 Inhibitors in the Therapeutics of Diabetes Mellitus: A Close Look beyond the Horizon
Volume: 19 Issue: 9
关键词: SGLT2,GLP-1,DPP-4,2型糖尿病,心血管,临床。
摘要: Cardiovascular complications are among the main reasons for the high morbidity and mortality in patients with type 2 diabetes, making the management of cardiovascular complications an integral component in the treatment of type 2 diabetes. Along the same line, the US Food and Drug Administration mandated all new diabetic drugs and therapies have a safe cardiovascular profile. Among various drugs available for the treatment against type 2 diabetes, the sodium-glucose cotransporter 2 (SGLT2) inhibitors represent a class of newly developed anti-diabetic agents with properties of mitigating cardiovascular risk in patients with type 2 diabetes. Evidence from clinical trials has suggested that the SGLT2 inhibitors empagliflozin and canagliflozin are capable of reducing the overall risk of cardiovascular events and mortality in type 2 diabetic patients. In this mini-review, we will briefly discuss the various cardiovascular benefits of SGLT2 inhibitors, and the underlying mechanisms involved.
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Cite this article as:
Cardiovascular Benefit of SGLT2 Inhibitors in the Therapeutics of Diabetes Mellitus: A Close Look beyond the Horizon, Current Drug Targets 2018; 19 (9) . https://dx.doi.org/10.2174/1389450119666180531102227
DOI https://dx.doi.org/10.2174/1389450119666180531102227 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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