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Review Article

饮食相关短链脂肪酸在结直肠癌的代谢和生存中的作用：预防和治疗意义。

卷 27, 期 24, 2020

页: [4087 - 4108] 页: 22

弟呕挨: 10.2174/0929867325666180530102050

价格: $65

摘要

大肠癌（CRC）是全球范围内与癌症相关的死亡的主要原因。 CRC风险增加与肠道菌群改变，短链脂肪酸（SCFA）产生减少有关。在人类结肠中产生的SCFA是未经消化的膳食纤维和淀粉细菌发酵的主要产物。结肠细胞使用乙酸，丙酸酯和丁酸酯这三种主要的SCFA作为能源，而转化的CRC细胞主要经历有氧糖酵解。与正常结肠细胞相比，CRC细胞对SCFA的敏感性增强，因此表明它们在细胞体内平衡中起着重要作用。因此，通过改变微生物群来控制肠道中的SCFA水平已成为一种潜在的CRC预防/治疗策略。近年来，人们对了解SCFA在CRC细胞中的作用机制的兴趣有所增加。几种SCFA转运蛋白如SMCT-1，MCT-1和水通道蛋白已被确定为肠道细胞中的主要跨膜转运蛋白。最近，显示乙酸盐促进MCT-1的质膜重新定位并触发葡萄糖代谢的变化。 SCFAs诱导CRC细胞凋亡，并发现了进一步的机制，包括溶酶体膜通透化与线粒体功能障碍和降解有关。在这篇综述中，我们将讨论CRC细胞转运SCFA的最新知识及其对CRC代谢和存活的影响。也将解决通过操纵结肠微生物群增加SCFA产生对CRC预防/治疗的影响。

关键词: 大肠癌，短链脂肪酸，微生物群，细胞死亡机制，新陈代谢，细胞死亡，膜转运。

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