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Review Article

白桦树皮三萜及其衍生物的抗癌研究

卷 27, 期 8, 2020

页: [1308 - 1336] 页: 29

弟呕挨: 10.2174/0929867325666180530095657

价格: $65

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摘要

白桦树皮三萜及其半合成衍生物具有广泛的生物学活性，包括对各种肿瘤细胞系的细胞毒性作用。但是，由于低溶解度和生物利用度，它们的医学应用受到很大限制。各种基于纳米技术的药物递送系统的使用是解决生物利用度不足的药物的快速发展的方法。在此，回顾了适用于桦树皮三萜结构的药物递送系统。桦树皮三萜类化合物及其半合成衍生物的上述缺点可以通过将它们掺入包括各种树枝状体系的有机纳米颗粒中，以及将活性化合物嵌入聚合物基质中或与碳水化合物纳米颗粒复合而没有共价键合来克服。一些已知的三萜类递送系统由纳米颗粒组成，所述纳米颗粒具有被碳水化合物或其他聚合物覆盖的无机核。通过包囊和乳化在亲脂性介质中递送目标化合物的方法也是合适的。此外，桦树皮三萜类化合物可以形成具有更高生物利用度的自组装系统。甚至，自组装系统还用作输送其他化学治疗剂的载体。除了增加生物利用度和抗癌活性外，另一个优点是，在大多数情况下，三萜类化合物与任何载体一起递送时，总体全身毒性降低。

关键词: 桦木素，桦木酸，齐墩果酸，羽扇豆酚，半合成衍生物，药物递送系统。

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