Current State of Nanomedicines in the Treatment of Topical Infectious Disorders

Title:Current State of Nanomedicines in the Treatment of Topical Infectious Disorders

Volume: 13 Issue: 2

Author(s): Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber and Om P. Katare*

Affiliation:

• University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014,India

Keywords: Topical, infections, liposomes, bacterial, fungal, nanoparticles.

Abstract: Background: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermines the need for the development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives.

Methods: The application of nanotechnology to medicine, or nanomedicine, is rapidly becoming a major driving force behind ongoing changes in the anti-infective field because of its interaction at the sub-atomic level with the skin tissue. The latter, in the current scenario, points towards vesicular carriers like liposomes, lipidic nanoparticles and silver nanoparticles. as the most promising drug delivery solutions for topical infection disorders. These have exhibited immense significance owing to their uniqueness to facilitate the interactions at interfaces with the barrier membranes.

Results: The present review summarizes the emerging efforts in combating topical infections particularly using nanomedicine based delivery systems as new tools to tackle the current challenges in treating infectious diseases. Besides, compiling various research reports, this article also includes formulation considerations, mechanisms of penetration and patents reported.

Conclusion: Despite the new emerging technologies and delivery systems, efforts are still needed in the right direction to combat this global challenge.

Cite this article as:

Thakur Kanika , Sharma Gajanand , Singh Bhupinder , Chhibber Sanjay and Katare P. Om *, Current State of Nanomedicines in the Treatment of Topical Infectious Disorders, Recent Patents on Anti-Infective Drug Discovery 2018; 13 (2) . https://dx.doi.org/10.2174/1574891X13666180529103804