Abstract
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Multi-Target Antitubercular Drugs
Volume: 18 Issue: 9
Author(s): Jessika de Oliveira Viana, Hamilton Mitsugu Ishiki, Marcus Tullius Scotti and Luciana Scotti*
Affiliation:
- Cheminformatics Laboratory, Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Campus I, 58051-900, Joao Pessoa-PB,Brazil
Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.
Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
Export Options
About this article
Cite this article as:
de Oliveira Viana Jessika , Ishiki Mitsugu Hamilton , Scotti Tullius Marcus and Scotti Luciana *, Multi-Target Antitubercular Drugs, Current Topics in Medicinal Chemistry 2018; 18 (9) . https://dx.doi.org/10.2174/1568026618666180528124414
DOI https://dx.doi.org/10.2174/1568026618666180528124414 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Toll Like Receptor - Potential Drug Targets in Infectious Disease
Infectious Disorders - Drug Targets Dendritic Cells: A Double-Edge Sword in Atherosclerotic Inflammation
Current Pharmaceutical Design Alkaptonuria, Ochronosis and Ochronotic Arthropathy in Mainland France and the Reunion Island. A Report of Clinical and Molecular Findings in 29 Patients
Current Rheumatology Reviews Use of Genetically Modified Bacteria to Modulate Adaptive Immunity
Current Gene Therapy Novel Applications of Recombinant Lactic Acid Bacteria in Therapy and in Metabolic Engineering
Recent Patents on Biotechnology Drug Repurposing for the Treatment of Staphylococcal Infections
Current Pharmaceutical Design The Hidden Face of Fetal Alcohol Spectrum Disorder
Current Women`s Health Reviews Evaluation of the QuantiFERON®-TB Gold In-Tube Assay and Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in an Iranian Referral Hospital
Infectious Disorders - Drug Targets A Comprehensive Systemic Literature Review of Pericardial Decompression Syndrome: Often Unrecognized and Potentially Fatal Syndrome
Current Cardiology Reviews Pharmacological Targeting of the Inflamed Intestinal Barrier
Current Pharmaceutical Design Nasal Polyposis: An Overview of Differential Diagnosis and Treatment
Recent Patents on Inflammation & Allergy Drug Discovery Articulating A Rights-Based Approach to HIV Treatment and Prevention Interventions
Current HIV Research Nitric Oxide: Friendly Rivalry in Tuberculosis
Current Signal Transduction Therapy Xenicane Natural Products: Biological Activity and Total Synthesis
Current Pharmaceutical Design Recent Advances on the Synthesis of Heterocycles from Diazo Compounds
Current Organic Chemistry Deep Transfer Learning for COVID-19 Prediction: Case Study for Limited Data Problems
Current Medical Imaging Monoamine Oxidase Inhibition and Molecular Modeling Studies of Piperidyl-thienyl and 2-Pyrazoline Derivatives of Chalcones
Medicinal Chemistry Docking Studies for Multi-Target Drugs
Current Drug Targets Development and Characterization of Spray Dried Microparticles for Pulmonary Delivery of Antifungal Drug
Current Drug Delivery Therapeutic Applications of Nanoemulsion Based Drug Delivery Systems: A Review of Patents in Last Two Decades
Recent Patents on Drug Delivery & Formulation