Abstract
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Multi-Target Antitubercular Drugs
Volume: 18 Issue: 9
Author(s): Jessika de Oliveira Viana, Hamilton Mitsugu Ishiki, Marcus Tullius Scotti and Luciana Scotti*
Affiliation:
- Cheminformatics Laboratory, Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Campus I, 58051-900, Joao Pessoa-PB,Brazil
Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.
Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
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Cite this article as:
de Oliveira Viana Jessika , Ishiki Mitsugu Hamilton , Scotti Tullius Marcus and Scotti Luciana *, Multi-Target Antitubercular Drugs, Current Topics in Medicinal Chemistry 2018; 18 (9) . https://dx.doi.org/10.2174/1568026618666180528124414
DOI https://dx.doi.org/10.2174/1568026618666180528124414 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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