Intestinal Crosstalk between Microbiota and Serotonin and its Impact on Gut Motility

Title:Intestinal Crosstalk between Microbiota and Serotonin and its Impact on Gut Motility

Volume: 19 Issue: 3

Author(s): Xiaolong Ge, Junhai Pan, Yichang Liu, Hongkan Wang, Wei Zhou*Xianfa Wang

Affiliation:

• Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou,China

Keywords: Intestinal microbiota, gut motility, bile acids, short chain fatty acids, serotonin, endocrine cells.

Abstract: Background: The gastrointestinal tract harbours a diverse bacterial community that contributes to health and disease. A number of studies have demonstrated that the gut microbiota plays a critical role in the metabolism of serotonin.

Methods: Microbial-derived metabolites, such as bile acids and short-chain fatty acids, are reported to affect the production of serotonin which, in turn, directly or indirectly regulates gut motility. Enterochromaffin cells are important specialized endocrine cells found in the intestine, which is the major location of serotonin biosynthesis. The relationship between microbiota and gut motility are studied depended on microbial-derived metabolites and serotonin.

Results and Conclusion: Both bile acids and short-chain fatty acids can modulate serotonin metabolism in hosts by affecting key intermediates of the serotonin pathway. Thus, gut motility may be regulated through microbial modifications of host serotonin biosynthesis, which continues to be evaluated as a target for functional gastrointestinal disorders.

Cite this article as:

Ge Xiaolong , Pan Junhai , Liu Yichang , Wang Hongkan , Zhou Wei *, Wang Xianfa , Intestinal Crosstalk between Microbiota and Serotonin and its Impact on Gut Motility, Current Pharmaceutical Biotechnology 2018; 19 (3) . https://dx.doi.org/10.2174/1389201019666180528094202