An Efficient and Straightforward Total Synthesis of (±)-Preclamol

Title:An Efficient and Straightforward Total Synthesis of (±)-Preclamol

Volume: 15 Issue: 12

Author(s): Ravi Lakkakula, K. Mukkanti and Arnab Roy*

Affiliation:

• GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad - 500076,India

Keywords: Michael addition, in-situ reduction/cyclization, preclamol, risperidone, alogliptin, ritalin.

Abstract: A prudent and scalable synthesis of (±)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-α-carbethoxy acetonitrile derivative as a key step.

Cite this article as:

Lakkakula Ravi, Mukkanti K. and Roy Arnab*, An Efficient and Straightforward Total Synthesis of (±)-Preclamol, Letters in Organic Chemistry 2018; 15 (12) . https://dx.doi.org/10.2174/1570178615666180518090406