Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans

Title:Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans

Volume: 24 Issue: 19

Author(s): Nikoletta Papaevgeniou and Niki Chondrogianni*

Affiliation:

• Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens,Greece

Keywords: Aging, senescence, aggregation, age-related diseases, C. elegans, polyphenols, longevity, stress resistance.

Abstract: Polyphenols constitute a group of compounds that have been highly investigated for their beneficial effects against various pathologic and non-pathologic conditions and diseases. Among their multi-faceted properties, their anti-oxidant potential nominates them as ideal protective candidates for conditions characterized by elevated levels of oxidative stress, including aging and age-related diseases. The nematode Caenorhabditis elegans is a multicellular model organism that is highly exploited in studies related to aging and age-associated pathologies. In this review, we will summarize studies where polyphenolic compounds have been tested for their anti-aging potential and their protective role against the progression of age-related diseases using C. elegans as their main model.

Cite this article as:

Papaevgeniou Nikoletta and Chondrogianni Niki *, Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans, Current Pharmaceutical Design 2018; 24 (19) . https://dx.doi.org/10.2174/1381612824666180515145652