摘要
本章探讨一些天然化合物的治疗靶点和抗炎性质,以及这些化合物在治疗慢性炎症疼痛状态中的当前或潜在用途。我们将综述慢性炎症疼痛的机制,选定的天然化合物抑制炎症疼痛的分子靶点,以及传统和目前使用这些化合物治疗疼痛的方法。以往的实验和临床疼痛的研究将从体外到动物模型和人类模型进行总结。还将讨论进一步研究的潜在领域。
关键词: 天然化合物,疼痛,炎症,神经病,分子靶点,药物开发。
图形摘要
Current Drug Targets
Title:Molecular Targets and Natural Compounds in Drug Development for the Treatment of Inflammatory Pain
Volume: 19 Issue: 16
关键词: 天然化合物,疼痛,炎症,神经病,分子靶点,药物开发。
摘要: This chapter explores therapeutic targets and the anti-inflammatory nature of some naturally- occurring compounds and the current or potential use of these compounds in the treatment of chronic inflammatory pain states. We will review the mechanisms of chronic inflammatory pain, the molecular targets of selected natural compounds in inhibiting inflammatory pain, and the traditional and current approaches to treating pain using these compounds. Previous research on experimental as well as clinical pain will be summarized from in vitro to animal and human models. Potential areas for further research will also be discussed.
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Cite this article as:
Molecular Targets and Natural Compounds in Drug Development for the Treatment of Inflammatory Pain, Current Drug Targets 2018; 19 (16) . https://dx.doi.org/10.2174/1389450119666180514120438
DOI https://dx.doi.org/10.2174/1389450119666180514120438 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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