摘要
背景:阿尔茨海默病(AD)是一种以记忆退化为特征的痴呆疾病,随着疾病的发展痴呆情况变得更严重。自由和线索选择性提醒测试(FCSRT)是用于评估这种缺陷的临床试验。然而,由于认知能力也取决于个体的心理生理状态,因此在执行测试期间通过外围自主活动监测状态是重要的。由于该技术的非接触特性,热红外成像已被用于这种评估,以保持医生和患者之间的自由和无偏见的互动。 目的:探讨面部温度参数在fcsrt中的变化是否反映了正常对照组(HC)早期自主神经状态的不同。 结果:在一组水平上,在测试过程中发现HC对AD的交感神经活动较强,表明AD患者fcsrt的表现具有抑制焦虑的作用。 结论:AD和HC可能在认知任务的执行过程中表现出不同的自主活动,提示高认知网络和情绪网络可能存在不同的调节机制。
关键词: 阿尔茨海默病,自由和线索选择性提醒测试,热成像,记忆缺陷,视觉空间缺陷,自主神经反应。
Current Alzheimer Research
Title:Assessment of the Autonomic Response in Alzheimer's Patients During the Execution of Memory Tasks: A Functional Thermal Imaging Study
Volume: 15 Issue: 10
关键词: 阿尔茨海默病,自由和线索选择性提醒测试,热成像,记忆缺陷,视觉空间缺陷,自主神经反应。
摘要: Background: Alzheimer’s disease (AD) is a form of dementia characterized by failure of memory that becomes more severe with the progression of the disease. The Free and Cued Selective Reminding Test (FCSRT) is a clinical test used to evaluate such a deficit. However, since the cognitive performances could depend also on the psychophysiological state of the individual, it is important to monitor that state through the peripheral autonomic activity during the execution of the test. Thermal infrared imaging has been used for this kind of assessment in order to preserve the free and unbiased interaction between doctor and patient, thanks to the contactless features of the technique.
Objective: To investigate whether the variation of facial temperature parameters during the FCSRT is indicative of different autonomic states in the early AD with respect to healthy controls (HC).
Results: At a group level, a greater sympathetic activity for the HC with respect to AD during the execution of the test was found, indicative of a suppression of anxiety associated with the performances of the FCSRT in AD patients.
Conclusion: These results indicate that AD and HC may present different autonomic activity associated with the execution of a cognitive task, thus suggesting a different modulation of high-cognition and emotion network.
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Cite this article as:
Assessment of the Autonomic Response in Alzheimer's Patients During the Execution of Memory Tasks: A Functional Thermal Imaging Study, Current Alzheimer Research 2018; 15 (10) . https://dx.doi.org/10.2174/1871529X18666180503125428
DOI https://dx.doi.org/10.2174/1871529X18666180503125428 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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